T3258

Tetracycline

98.0-102.0% (HPLC)

• Synonim(y): Tetracycline Hydrate
• Wzór empiryczny (zapis Hilla): C₂₂H₂₄N₂O₈ · xH₂O
• Numer CAS: 60-54-8
• Masa cząsteczkowa: 444.43 (anhydrous basis)
• UNSPSC Code: 51284017
• NACRES: NA.85
• PubChem Substance ID: 24900120
• EC Number: 200-481-9
• Beilstein/REAXYS Number: 2230417
• MDL number: MFCD00151232

Właściwości

• Quality Segment: 200
• assay: 98.0-102.0% (HPLC)
• form: powder or crystals
• storage condition: (Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)
• color: faint yellow to dark yellow
• antibiotic activity spectrum: Gram-negative bacteria, Gram-positive bacteria
• mode of action: protein synthesis | interferes
• storage temp.: 2-8°C
• SMILES string: CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c4c(O)cccc4[C@@]3(C)O
• InChI: 1S/C22H24N2O8/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28/h4-6,9-10,15,25,27-28,31-32H,7H2,1-3H3,(H2,23,30)/t9-,10-,15-,21+,22-/m0/s1
• InChI key: OFVLGDICTFRJMM-WESIUVDSSA-N
• Gene Information: human ... CYP1A2(1544), TERT(7015)

Opis

General description

Chemical structure: tetracycline

Biochem/physiol Actions

Mode of Action: Tetracycline passively diffuses through proin channels in the cell membrane, binding to 30S ribosomes and inhibits protein synthesis by preventing access of aminoacyl tRNA to the acceptor site on the mRNA-ribosome complex. It also binds to the bacterial 50S ribosomal subunit, altering the membrane and causing intracellular components to leak from bacterial cells. The inhibitory effects can be reversed by washing, suggesting that it is the reversibly bound antibiotic, and not the irreversibly bound drug, that is responsible for antibacterial action.

Mode of Resistance: The effects are inactivated via a loss of cell wall permeability.

Antimicrobial spectrum: Includes a wide range of antimicrobial activity against gram-positive and gram-negative bacteria.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS08,GHS07,GHS09
• Słowo ostrzegawcze: Warning
• Kody zagrożeń: H302,H361fd,H411
• Ostrzeżenia: P202 - P264 - P270 - P273 - P301 + P312 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Chronic 2 - Repr. 2
• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• PPE (środki ochrony indywidualnej): dust mask type N95 (US), Eyeshields, Gloves