T3455

Terameprocol

≥98% (HPLC)

• Synonim(y): 2,3-Dimethyl-1,4-bis-(3,4-dimethoxyphenyl)butane, EM-1421, M4N, TMNDGA, Tetra-O-methyl nordihydroguaiaretic acid, rel-4-[(2R,3S)-4-(3,4-Dimethoxyphenyl)-2,3-dimethylbutyl]-1,2-dimethoxybenzene, tetra-O-methyl-NDGA, tetramethyl NDGA, tetramethyl Nordihydroguaiaretic Acid
• Wzór empiryczny (zapis Hilla): C₂₂H₃₀O₄
• Numer CAS: 24150-24-1
• Masa cząsteczkowa: 358.47
• NACRES: NA.77
• PubChem Substance ID: 329826768
• UNSPSC Code: 12352200
• MDL number: MFCD11113155
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to off-white
• solubility: DMSO: ≥10 mg/mL
• storage temp.: −20°C
• SMILES string: COc1ccc(C[C@H](C)[C@H](C)Cc2ccc(OC)c(OC)c2)cc1OC
• InChI: 1S/C22H30O4/c1-15(11-17-7-9-19(23-3)21(13-17)25-5)16(2)12-18-8-10-20(24-4)22(14-18)26-6/h7-10,13-16H,11-12H2,1-6H3/t15-,16+
• InChI key: ORQFDHFZSMXRLM-IYBDPMFKSA-N

Opis

Biochem/physiol Actions

Terameprocol is a synthetic derivative of NDGA, a non-selective lipoxygenase inhibitor.

Terameprocol is a synthetic derivative of NDGA, a non-selective lipoxygenase inhibitor. It inhibits Sp1 transcription factor binding at the HIV long terminal repeat promoter and at the α-ICP4 promoter, a gene essential for HSV replication, with IC50 values of 11 and 43.5 μM respectively. TMNDGA induces growth arrest and apoptosis by suppressing Sp1-dependent Cdc2 and survivin gene expression giving rise to its antitumorigenic activity. The in vivo growth of xenografts in numerous human tumor types was suppressed upon treatment with TMNDGA It also inhibits the growth of murine and human melanomas and human colon cancer in vivo without causing other tissue toxicity.

Terameprocol is known to reduce angiogenesis¹.

Preparation Note

Terameprocol is soluble in DMSO at a concentration that is greater than or equal to 10 mg/ml.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS09
• Słowo ostrzegawcze: Warning
• Kody zagrożeń: H410
• Ostrzeżenia: P273 - P391 - P501
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1
• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable