T6069

Thio-TEPA

• Synonim(y): N,N′,N″-Triethylenethiophosphoramide, Thio-Tep, Thiofozil, Thiotef, Tio-tef, Tiofosfamid, Tiofosyl, Tiofozil, Tris(aziridinyl)phosphine sulfide
• Wzór empiryczny (zapis Hilla): C₆H₁₂N₃PS
• Numer CAS: 52-24-4
• Masa cząsteczkowa: 189.22
• NACRES: NA.85
• PubChem Substance ID: 24900346
• UNSPSC Code: 51102829
• EC Number: 200-135-7
• MDL number: MFCD00145452

Właściwości

• form: solid
• Quality Segment: 200
• storage condition: (Keep container tightly closed in a dry and well-ventilated place.)
• color: white
• antibiotic activity spectrum: neoplastics
• mode of action: DNA synthesis | interferes
• storage temp.: 2-8°C
• SMILES string: S=P(N1CC1)(N2CC2)N3CC3
• InChI: 1S/C6H12N3PS/c11-10(7-1-2-7,8-3-4-8)9-5-6-9/h1-6H2
• InChI key: FOCVUCIESVLUNU-UHFFFAOYSA-N

Opis

General description

Chemical structure: aziridine

Application

A polyfunctional alkylating agent

Biochem/physiol Actions

The unstable nitrogen-carbon groups alkylate with DNA which causes irreversible DNA damage. They stop tumor growth by crosslinking guanine nucleobases in DNA double-helix strands, directly attacking DNA. The DNA strands are unable to uncoil and separate which halts cell division.

Analysis Note

Solubility - freely soluble in water , in chloroform and in ethanol (96%)

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS06,GHS08
• Słowo ostrzegawcze: Danger
• Kody zagrożeń: H300,H350
• Ostrzeżenia: P202 - P264 - P280 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 2 Oral - Carc. 1B
• Klasa składowania: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Co się dzieje?: WGK 3
• PPE (środki ochrony indywidualnej): Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges