T6575

TOFA

≥98% (HPLC)

• Synonim(y): 5-(Tetradecyloxy)-2-furoic acid
• Wzór empiryczny (zapis Hilla): C₁₉H₃₂O₄
• Numer CAS: 54857-86-2
• Masa cząsteczkowa: 324.45
• NACRES: NA.77
• PubChem Substance ID: 329826849
• UNSPSC Code: 12352200
• MDL number: MFCD01726059
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Quality Segment: 200
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• mp: 112-115 °C
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: −20°C
• SMILES string: CCCCCCCCCCCCCCOc1ccc(o1)C(O)=O
• InChI: 1S/C19H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22-18-15-14-17(23-18)19(20)21/h14-15H,2-13,16H2,1H3,(H,20,21)
• InChI key: CZRCFAOMWRAFIC-UHFFFAOYSA-N

Opis

Application

TOFA has been used as an ACC inhibitor to study its effect on insulin secretion in INS-1E cells.

TOFA has been used as a lipid biosynthesis inhibitor in mesenchymal stromal cells (MSCs), human pluripotent stem cells., an acetyl-CoA carboxylase 1 inhibitor in murine adipocyte cell lines., a lipolysis inhibitor in cancer stem cells (CSCs).

Biochem/physiol Actions

TOFA is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC).

TOFA is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC). TOFA is a key enzyme involved in fatty acid biosynthesis. TOFA inhibits cellular fatty acid synthesis in a dose-dependent manner (IC₅₀ = 4 μM in human breast cancer cell line MCF7).

Studies have reported that TOFA can inhibit the anorectic effect of subcutaneous tamoxifen (TMX) on food intake during refeeding experiments in rats.

5-(Tetradecyloxy)-2-furoic acid (TOFA) elicits hypolipidemic functionality by favoring fatty acid breakdown and at the same time preventing biosynthesis. It induces apoptosis in pancreatic cancer cells and favors tumor suppression.

Preparation Note

TOFA is soluble in DMSO at a concentration that is greater than 2 mg/ml.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 2
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• PPE (środki ochrony indywidualnej): Eyeshields, Gloves, type N95 (US)