T6700

TRAM-34

≥98% (HPLC), Ca2+-activated K+ channel inhibitor, solid

• Synonim(y): 1-[(2-Chlorophenyl)diphenylmethyl]-1H-pyrazole
• Wzór empiryczny (zapis Hilla): C₂₂H₁₇ClN₂
• Numer CAS: 289905-88-0
• Masa cząsteczkowa: 344.84
• UNSPSC Code: 12352200
• PubChem Substance ID: 329826852
• NACRES: NA.77
• MDL number: MFCD09842562
• Assay: ≥98% (HPLC)
• Form: solid

Właściwości

• Nazwa produktu: TRAM-34, ≥98% (HPLC), solid
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• color: off-white
• solubility: DMSO: 2 mg/mL, H₂O: insoluble
• storage temp.: 2-8°C
• SMILES string: Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4cccn4
• InChI: 1S/C22H17ClN2/c23-21-15-8-7-14-20(21)22(25-17-9-16-24-25,18-10-3-1-4-11-18)19-12-5-2-6-13-19/h1-17H
• InChI key: KBFUQFVFYYBHBT-UHFFFAOYSA-N

Opis

Application

TRAM-34 has been used to study its effect on the prevention of vascular restenosis after balloon angioplasty.

Biochem/physiol Actions

TRAM-34 is a potent inhibitor of the intermediate-conductance Ca²⁺-activated K⁺ channel.

TRAM-34 exhibits 100-fold selectivity (K_d = 20 nM) for IK_Ca1 channels over other K⁺ channels (Charybdotoxin, K_d = 5 nM, Clotrimazole, K_d = 70 nM; Nitrendipine K_d = 900 nM). Furthermore, TRAM-34 is known to suppress the activation of human T lymphocytes,.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

TRAM-34 is soluble in DMSO at 2 mg/ml. However, it is insoluble in water.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS07
• Słowo ostrzegawcze: Warning
• Kody zagrożeń: H302,H413
• Ostrzeżenia: P264 - P270 - P273 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Chronic 4
• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• PPE (środki ochrony indywidualnej): dust mask type N95 (US), Eyeshields, Gloves