T7165

Tyrphostin 23

≥98%

• Synonim(y): (3,4-Dihydroxybenzylidene)malononitrile, RG-50810
• Wzór empiryczny (zapis Hilla): C₁₀H₆N₂O₂
• Numer CAS: 118409-57-7
• Masa cząsteczkowa: 186.17
• NACRES: NA.77
• PubChem Substance ID: 24278041
• UNSPSC Code: 12352200
• MDL number: MFCD00133899
• Assay: ≥98%
• Form: powder

Właściwości

• biological source: synthetic (organic)
• Quality Segment: 100
• assay: ≥98%
• form: powder
• potency: 35 μM IC₅₀
• solubility: DMSO: soluble 50 mg/mL, clear, yellow to brownish-yellow
• storage temp.: 2-8°C
• SMILES string: Oc1ccc(cc1O)\C=C(\C#N)C#N
• InChI: 1S/C10H6N2O2/c11-5-8(6-12)3-7-1-2-9(13)10(14)4-7/h1-4,13-14H
• InChI key: VTJXFTPMFYAJJU-UHFFFAOYSA-N
• Gene Information: human ... CDK2(1017)

Opis

Application

Tyrphostin 23 can be used as a tyrosine kinase inhibitor for studying rat ghrelin-induced MAPK stimulation in GH3 cells. Tyrphostin 23 has also been used to analyze its effects on secretoneurin (SN)-induced chemotaxis of neutrophils.

Biochem/physiol Actions

Tyrphostin 23 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain,.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• PPE (środki ochrony indywidualnej): Eyeshields, Gloves, type N95 (US)