T7383

Tetracaine

≥98% (TLC)

• Synonim(y): 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester
• Wzór empiryczny (zapis Hilla): C₁₅H₂₄N₂O₂
• Numer CAS: 94-24-6
• Masa cząsteczkowa: 264.36
• NACRES: NA.32
• PubChem Substance ID: 57654695
• UNSPSC Code: 12352200
• EC Number: 202-316-6
• MDL number: MFCD00053787
• Assay: ≥98% (TLC)
• Form: powder

Właściwości

• biological source: synthetic (organic)
• Quality Segment: 200
• assay: ≥98% (TLC)
• form: powder
• technique(s): toxicology assay: suitable
• storage temp.: 2-8°C
• SMILES string: CCCCNc1ccc(cc1)C(=O)OCCN(C)C
• InChI: 1S/C15H24N2O2/c1-4-5-10-16-14-8-6-13(7-9-14)15(18)19-12-11-17(2)3/h6-9,16H,4-5,10-12H2,1-3H3
• InChI key: GKCBAIGFKIBETG-UHFFFAOYSA-N
• Gene Information: human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335) ;

Opis

General description

Tetracaine belongs to the amino-ester class and has a pKa of 8.46.

Application

Topical ophthalmic anesthetic; used for spinal anesthesia

Tetracaine has been used as an anesthetic and to lower the glucose synthesis in upper small intestinal infusions. It has also been used to inhibit ryanodine receptors (RyRs) in rats.

Tetracaine can be used as a research tool for studying E-C coupling in both skeletal as well as cardiac muscle. The product is a local anaesthetic drug used for studying the impact of numerous drugs on Tumour-necrosis-factor (TNF)-mediated cytotoxicity as well as TNF-induced arachidonic acid release.

Biochem/physiol Actions

Blocks voltage-sensitive release of Ca²⁺ from sarcoplasmic reticulum.

Tetracaine blocks intracellular sodium channels. It mediates phosphorylation of eukaryotic initiation factor 2 (eIF2 α) via translational inhibition of P-body formation.

Tetracaine also refers as 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester interfere with calcium movement in muscle and non-muscle cells and can inhibit potassium-induced as well as caffeine-induced shortening of outer hair cells (OHC′s). But, the product can′t inhibit electrically-induced shortening of OHC′s.The product can also stimulate caspase activation and inhibits pro-survival signalling pathways which in turn induce human renal cell apoptosis.

Preparation Note

250 mg of tetracaine dissolves in 5 ml of EtOH to yield a clear, colorless solution. The product is also soluble in chloroform and ether at a ratio of 1:2 and in ethanol at 1:5. It is very slightly soluble in water.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS06,GHS08
• Słowo ostrzegawcze: Danger
• Kody zagrożeń: H301,H317,H351
• Ostrzeżenia: P201 - P280 - P301 + P310 + P330 - P302 + P352
• Hazard Classifications: Acute Tox. 3 Oral - Carc. 2 - Skin Sens. 1
• Klasa składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3