U3385

UA62784

≥98% (HPLC)

• Synonim(y): 4-[5-(4-Methoxyphenyl)-2-oxazolyl]-9H-Fluoren-9-one
• Wzór empiryczny (zapis Hilla): C₂₃H₁₅NO₃
• Numer CAS: 313367-92-9
• Masa cząsteczkowa: 353.37
• NACRES: NA.77
• PubChem Substance ID: 329827627
• UNSPSC Code: 12352202
• MDL number: MFCD00489199
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: yellow
• solubility: DMSO: >2 mg/mL
• storage temp.: 2-8°C
• SMILES string: COc1ccc(cc1)-c2cnc(o2)-c3cccc4C(=O)c5ccccc5-c34
• InChI: 1S/C23H15NO3/c1-26-15-11-9-14(10-12-15)20-13-24-23(27-20)19-8-4-7-18-21(19)16-5-2-3-6-17(16)22(18)25/h2-13H,1H3
• InChI key: SVICLWPFAQYZLX-UHFFFAOYSA-N

Opis

Biochem/physiol Actions

UA62784 is a specific inhibitor of centromere protein E (CENPE) kinesin-like protein; mitotic inhibitor.

UA62784 is a specific inhibitor of centromere protein E (CENPE) kinesin-like protein; mitotic inhibitor. CENP-E is a kinesin-like motor protein that localizes to the kinetochore during mitosis and is essential for bipolar spindle formation. UA62784 is a novel specific inhibitor of CENP-E, which likely binds within the motor domain of CENP-E. UA62784 causes reversible cell cycle arrest in mitosis before metaphase, which leads to apoptosis. The compound is not interacting with microtubules directly.

Studies have also reported that UA62784 associates with tubulin at or near the colchicine-binding sites in cells and functions as a cytotoxic, microtubule inhibitor.

Preparation Note

UA62784 is soluble in DMSO at a concentration >2 mg/ml.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS07
• Słowo ostrzegawcze: Warning
• Kody zagrożeń: H302
• Ostrzeżenia: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable