V3639

Valinomycin

Ready Made Solution, ~1 mg/mL in DMSO

• Synonim(y): Cyclo(L-Val-D-HyIva-D-Val-L-Lac-)₃: HyIva = α-Hydroxyisovaleric acid, Lac = Lactic acid
• Wzór empiryczny (zapis Hilla): C₅₄H₉₀N₆O₁₈
• Numer CAS: 2001-95-8
• Masa cząsteczkowa: 1111.32
• UNSPSC Code: 51102829
• NACRES: NA.76
• PubChem Substance ID: 24900743
• MDL number: MFCD00005114
• Beilstein/REAXYS Number: 78657

Właściwości

• biological source: Streptomyces sp.
• Quality Segment: 200
• assay: ≥90% (HPLC)
• form: liquid, ready-to-use solution
• storage condition: (Keep container tightly closed in a dry and well-ventilated place. Hydroscopic.)
• concentration: ~1 mg/mL in DMSO
• color: colorless
• antibiotic activity spectrum: Gram-positive bacteria, parasites, viruses
• mode of action: cell membrane | interferes
• shipped in: wet ice
• storage temp.: 2-8°C
• SMILES string: CC(C)[C@@H]1NC(=O)[C@H](C)OC(=O)[C@@H](NC(=O)[C@H](OC(=O)[C@@H](NC(=O)[C@H](C)OC(=O)[C@H](NC(=O)[C@H](OC(=O)[C@@H](NC(=O)[C@H](C)OC(=O)[C@H](NC(=O)[C@H](OC1=O)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C
• InChI: 1S/C54H90N6O18/c1-22(2)34-49(67)73-31(19)43(61)55-38(26(9)10)53(71)77-41(29(15)16)47(65)59-36(24(5)6)51(69)75-33(21)45(63)57-39(27(11)12)54(72)78-42(30(17)18)48(66)60-35(23(3)4)50(68)74-32(20)44(62)56-37(25(7)8)52(70)76-40(28(13)14)46(64)58-34/h22-42H,1-21H3,(H,55,61)(H,56,62)(H,57,63)(H,58,64)(H,59,65)(H,60,66)/t31-,32-,33-,34-,35+,36+,37-,38-,39-,40+,41+,42+/m0/s1
• InChI key: FCFNRCROJUBPLU-RPUZOQEISA-N

Opis

General description

Chemical structure: peptide

Application

Valinomycin is a cyclic dodecadepsipeptides with potassium ionophoric properties. It is used to study ion transport in biological systems. It is used to study its inhibitory effect on intact cells and the growth of bacteria and yeast. It is used to induce apoptosis.

Biochem/physiol Actions

Valinomycin is a K+-selective ionophoric cyclodepsipeptide. It is a potassium ionophore which uncouples oxidative phosphorylation, induces apoptosis in murine thymocytes, inhibits NGF-induced neuronal differentiation and antagonizes ET-induced vasoconstriction. It is reported to be insecticidal, nematicidal and antiviral.

K⁺-selective ionophore which uncouples oxidative phosphorylation.

K⁺-selective ionophoric cyclodepsipeptide; potassium ionophore which uncouples oxidative phosphorylation, induces apoptosis in murine thymocytes, inhibits NGF-induced neuronal differentiation and antagonizes ET-induced vasoconstriction.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Hygroscopic.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 10 - Combustible liquids
• Co się dzieje?: WGK 1
• Temperatura zapłonu (°F): 188.6 °F - closed cup
• Temperatura zapłonu (°C): 87 °C - closed cup
• PPE (środki ochrony indywidualnej): Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter