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W4394
Withaferin A
≥95% (HPLC)
Synonim(y):
5,6-Epoxy-4,27-dihydroxy-1-oxowitha-2,24-dienolide, Withaferine A
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| Rozmiar/SKU | Dostępność | Cena netto |
|---|---|---|
5 mg | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 2510,00 zł 1882,50 zł |
Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C28H38O6
Numer CAS:
Masa cząsteczkowa:
470.60
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352211
MDL number:
1882,50 zł
Cena katalogowa2510,00 złZaoszczędź 25%Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
Pomoc techniczna
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Pozwól nam pomócbiological source
plant (Withania somnifera)
Quality Segment
assay
≥95% (HPLC)
form
powder
mp
252-253 °C
functional group
epoxy, ketone
shipped in
ambient
storage temp.
2-8°C
SMILES string
C[C@H]([C@H]1CC(C)=C(CO)C(=O)O1)[C@H]2CC[C@H]3[C@@H]4C[C@H]5O[C@]56[C@@H](O)C=CC(=O)[C@]6(C)[C@H]4CC[C@]23C
InChI
1S/C28H38O6/c1-14-11-21(33-25(32)17(14)13-29)15(2)18-5-6-19-16-12-24-28(34-24)23(31)8-7-22(30)27(28,4)20(16)9-10-26(18,19)3/h7-8,15-16,18-21,23-24,29,31H,5-6,9-13H2,1-4H3/t15-,16-,18+,19-,20-,21+,23-,24+,26+,27-,28+/m0/s1
InChI key
DBRXOUCRJQVYJQ-CKNDUULBSA-N
Application
Withaferin A was used to treat HEK293 cells to study its effect on cystic fibrosis inflammation.
Biochem/physiol Actions
Withaferin A is a steroidal lactone that is isolated from the plant Withania somnifera. It has potent anti-inflammatory properties as it inhibits the activation of NF-κ B signaling pathway. The anti-tumor activity of Withaferin A is due to its ability to alter cytoskeletal architecture by binding annexin II and disrupting F actin cross-links. Withaferin A also inhibits angiogenesis by binding to vimentin and F-actin.
Steroidal lactone that exhibits cytotoxicity towards tumor cells. Protective effects attributed to anti-lipid peroxidative, antioxidant and detoxifying functionality.
Preparation Note
Withaferin A yields a clear, colorless solution in methanol at 1 mg/ml.
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Ta pozycja | |||
|---|---|---|---|
| description ≥95% (HPLC) | description phyproof® Reference Substance | description A cell-permeable steroidal lactone that displays antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties. | description ≥98% (HPLC) |
| biological source plant (Withania somnifera) | biological source - | biological source - | biological source - |
| functional group epoxy, ketone | functional group - | functional group - | functional group - |
| assay ≥95% (HPLC) | assay ≥95.0% (HPLC) | assay ≥94% (HPLC) | assay ≥98% (HPLC) |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| form powder | form - | form solid | form powder |
| shipped in ambient | shipped in - | shipped in ambient | shipped in - |
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Klasa składowania
13 - Non Combustible Solids
Co się dzieje?
WGK 3
Temperatura zapłonu (°F)
438.8 °F
Temperatura zapłonu (°C)
226 °C
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How does one solubilize Product W4394, Withaferin A?
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Sigma-Aldrich tests Product W4394, Withaferin A, for solubility using methanol at a concentration of 1 mg/mL. Information in our files indicates that it is also soluble in DMSO and ethanol.
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What is the solution stability of Product W4394, Withaferin A?
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Sigma-Aldrich does not test the Product W4394, Withaferin A, for solution stability. Information in our files indicates that although it is best to use freshly prepared solution when possible. However, if stock solutions must be stored, we would recommend they be stored in frozen aliquots at -20°C or below for about one month.
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How does the storage temperature relate to shipping conditions?
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The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.
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