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X1875

Xanthine Oxidase from bovine milk

Name: Xanthine Oxidase from bovine milk
Brand: SIGMA
Price: 404 PLN

Grade I, ammonium sulfate suspension, ≥0.4 units/mg protein

Synonim(y):

XOD, Xanthine:oxygen oxidoreductase

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Rozmiar/SKU	Dostępność	Cena netto
5 units	Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności	404,00 zł
25 units	Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności	735,00 zł
50 units	Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności	1260,00 zł

Informacje o tej pozycji

Numer CAS:

9002-17-9

UNSPSC Code:

12352204

NACRES:

NA.54

EC Number:

232-657-6

MDL number:

MFCD00082145

Numer WE:

1.17.3.2.

Specific activity:

≥0.4 units/mg protein

404,00 zł

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Właściwości

type

Grade I

Quality Segment

200

form

ammonium sulfate suspension

specific activity

≥0.4 units/mg protein

foreign activity

uricase ≤0.5%

shipped in

wet ice

storage temp.

2-8°C

Opis

General description

Xanthine Oxidase (XOD) is a metal flavoprotein. It has flavin adenine dinucleotide (FAD), molybdenum and iron in the ratio 2:2:8. This homodimer has a molecule weight of 290kDa. It is a member of the molybdenum-protein family. This enzyme consists of two separated substrate-binding sites.

Formerly E.C. 1.1.3.22

Application

Xanthine Oxidase from bovine milk has been used:

in the preparation of xanthine oxidase (XO) solution for 5-(diethoxyphosphoryl)-5-methyl-1-pyrroline-N-oxide (DEPMPO)-spin trapping assay
in in vitro XO assay for screening Vietnamese medicinal plants for XO inhibitory activity
as a standard to determine XO activity
as a standard to test the synergistic effect of docosahexaenoic acid (DHA)

Biochem/physiol Actions

Hydroxylation of hypoxanthine to xanthine and xanthine to uric acid is catalyzed by xanthinebb oxidase (XO) enzyme.

Xanthine oxidase was shown to be involved in the reduction of cytochrome c by the generation of superoxide anions following the oxidation of xanthine. These free radicals are responsible for reducing cytochrome c.

Xanthine oxidase is a molybdenum-containing enzyme that is found in the cytosol, and may be strongly inhibited by flavonoids. It plays a vital role in the metabolism of some drugs, as well as purines and pyrimidines. It is also known to be a biological source of reactive oxygen species.

Physical form

Suspension in 2.3 M (NH₄)₂SO₄ containing 1 mM sodium salicylate

Analysis Note

Protein determined by biuret

Other Notes

One unit will convert 1.0 μmole of xanthine to uric acid per min at pH 7.5 at 25 °C. Approx. 50% of the activity is obtained with hypoxanthine as substrate.

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Ta pozycja	X4875	X4376	X4500
Sigma-Aldrich X1875 Xanthine Oxidase from bovine milk	Sigma-Aldrich X4875 Xanthine Oxidase from bovine milk	Sigma-Aldrich X4376 Xanthine Oxidase from bovine milk	Sigma-Aldrich X4500 Xanthine Oxidase from bovine milk
description Grade I, ammonium sulfate suspension, ≥0.4 units/mg protein	description Grade IV, ammonium sulfate suspension, ≥0.1 units/mg protein	description lyophilized powder, 0.4-1.0 units/mg protein	description Grade III, ammonium sulfate suspension, ≥0.8 units/mg protein
specific activity ≥0.4 units/mg protein	specific activity ≥0.1 units/mg protein	specific activity 0.4-1.0 units/mg protein	specific activity ≥0.8 units/mg protein
form ammonium sulfate suspension	form ammonium sulfate suspension	form lyophilized powder	form ammonium sulfate suspension
shipped in wet ice	shipped in -	shipped in -	shipped in -
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
foreign activity uricase ≤0.5%	foreign activity -	foreign activity -	foreign activity uricase ≤0.1%
Quality Level 200	Quality Level 200	Quality Level 300	Quality Level 200