1029501

Besylan amlodypiny

United States Pharmacopeia (USP) Reference Standard

• Synonim(y): Amlodipine besylate, 2-[(2-Aminoethoxy)-methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5- pyridinedicarboxylic acid 3-ethyl 5-methyl ester benzene sulfonate, Norvasc
• Wzór empiryczny (zapis Hilla): C₂₀H₂₅ClN₂O₅ · C₆H₅SO₃H
• Numer CAS: 111470-99-6
• Masa cząsteczkowa: 567.05
• NACRES: NA.24
• PubChem Substance ID: 329749008
• UNSPSC Code: 41116107
• MDL number: MFCD00887594

Właściwości

• grade: pharmaceutical primary standard
• agency: USP
• API family: amlodipine
• manufacturer/tradename: USP
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-8°C
• SMILES string: OS(=O)(=O)c1ccccc1.CCOC(=O)C2=C(COCCN)NC(C)=C(C2c3ccccc3Cl)C(=O)OC
• InChI: 1S/C20H25ClN2O5.C6H6O3S/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21;7-10(8,9)6-4-2-1-3-5-6/h5-8,17,23H,4,9-11,22H2,1-3H3;1-5H,(H,7,8,9)
• InChI key: ZPBWCRDSRKPIDG-UHFFFAOYSA-N
• Gene Information: human ... CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779)

Opis

General description

Find answers to frequently asked questions on USP products in USP FAQs.

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Wzorzec referencyjny besylanu amlodypiny USP, przeznaczony do stosowania w określonych testach jakości i oznaczeniach, jak określono w kompendiach USP. Również do użytku z monografiami USP, takimi jak:

• Amlodipine and Atorvastatin Tablets (Tabletki amlodypiny i atorwastatyny)
• Amlodypina i chlorowodorek benazeprylu w kapsułkach
• Amlodypina i olmesartan medoksomil tabletki
• Tabletki amlodypiny i walsartanu
• Besylan amlodypiny
• Besylan amlodypiny Tabletki
• Złożona zawiesina doustna amlodypiny

Biochem/physiol Actions

Amlodipine besylate is an L-type calcium channel blocker.

Amlodipine is an L-type calcium channel blocker. Amlodipine belongs to a class of cardiovascular drugs, which act at the voltage gated calcium channel of the Ca_V1, or L-type, class. Amlodipine also has antihypertensive and antianginal effects. Its activity resides mainly in the (-)-isomer. Amlodipine inhibits growth of human epidermoid carcinoma A431 cells and has antireproductive effects in male rats.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

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Informacja o środkach bezpieczeństwa

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Klasa składowania: 11 - Combustible Solids
• flash_point_f: Not applicable
• flash_point_c: Not applicable