1605012

Roflumilast

United States Pharmacopeia (USP) Reference Standard

• Synonim(y): 3-(Cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)benzamide, 3-Cyclopropylmethoxy-4-difluoromethoxy-N-[3,5-dichloropyrid-4-yl]-benzamide
• Wzór empiryczny (zapis Hilla): C₁₇H₁₄Cl₂F₂N₂O₃
• Numer CAS: 162401-32-3
• Masa cząsteczkowa: 403.21
• MDL number: MFCD00938270
• NACRES: NA.24
• UNSPSC Code: 41116107

Właściwości

• grade: pharmaceutical primary standard
• agency: USP
• manufacturer/tradename: USP
• application(s): pharmaceutical small molecule
• format: neat
• storage temp.: 2-8°C
• SMILES string: ClC1=CN=CC(Cl)=C1NC(C2=CC=C(OC(F)F)C(OCC3CC3)=C2)=O
• InChI: 1S/C17H14Cl2F2N2O3/c18-11-6-22-7-12(19)15(11)23-16(24)10-3-4-13(26-17(20)21)14(5-10)25-8-9-1-2-9/h3-7,9,17H,1-2,8H2,(H,22,23,24)
• InChI key: MNDBXUUTURYVHR-UHFFFAOYSA-N

Opis

General description

Find answers to frequently asked questions on USP products in USP FAQs.

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including MSDS and any product information leaflets, have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Biochem/physiol Actions

Roflumilast is a highly potent, orally active, and selective phosphodiesterase 4 (PDE4) inhibitor with an IC₅₀ of 0.8 nM. Roflumilast has anti-inflammatory properties and is used clinically to treat COPD.

Roflumilast is a highly potent, orally active, and selective phosphodiesterase 4 (PDE4) inhibitor.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

Other Notes

Sales restrictions may apply.

USP issued SDS can be found here

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS07
• Słowo ostrzegawcze: Warning
• Kody zagrożeń: H315,H319,H335
• Ostrzeżenia: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Narządy docelowe: Respiratory system
• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): No data available
• Temperatura zapłonu (°C): No data available