G6133
L-谷氨酸 γ-（对硝基苯胺） 盐酸盐
≥98% (HPLC), glutamine (Gln) transporter alanine-serine-cysteine transporter 2 (ASCT2) blocker, powder
别名:
Lγ-谷氨酰-对-硝基苯胺
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关于此项目
经验公式（希尔记法）:
C11H13N3O5 · HCl
化学文摘社编号:
分子量:
303.70
EC號碼:
MDL號碼:
分類程式碼代碼:
12352204
PubChem物質ID:
NACRES:
NA.83
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产品名称
L-谷氨酸 γ-（对硝基苯胺） 盐酸盐, γ-glutamyl transpeptidase substrate
品質等級
化驗
≥98% (HPLC)
形狀
powder
溶解度
water: 5 mg/mL, clear, yellow
儲存溫度
2-8°C
SMILES 字串
Cl.NC(CCC(=O)Nc1ccc(cc1)N(=O)=O)C(O)=O
InChI
1S/C11H13N3O5.ClH/c12-9(11(16)17)5-6-10(15)13-7-1-3-8(4-2-7)14(18)19;/h1-4,9H,5-6,12H2,(H,13,15)(H,16,17);1H
InChI 密鑰
OJEVFSFTVARWQX-UHFFFAOYSA-N
相关类别
1 of 4
此商品 | G1135 | 49525 | G2505 |
|---|---|---|---|
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥99.0% (TLC) | assay ≥98% (HPLC) |
| solubility water: 5 mg/mL, clear, yellow | solubility formic acid: 50 mg/mL, clear to slightly hazy | solubility H2O: 100 mg/mL, clear, yellow-green | solubility methanol with 1 M NH4OH: 50 mg/mL, clear to slightly hazy |
| Quality Level 300 | Quality Level 200 | Quality Level 200 | Quality Level 100 |
| form powder | form powder | form powder | form powder |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −20°C |
一般說明
γ-谷氨酰胺转肽酶底物
應用
生化／生理作用
L-谷氨酰对硝基苯胺（GPNA）通常用于阻断谷氨酰胺（Gln）转运蛋白丙氨酸丝氨酸半胱氨酸转运蛋白 2（ASCT2）。它还可以抑制钠依赖性和非依赖性氨基酸转运蛋白。GPNA是γ-谷氨酰转移酶（GGT）底物，在γ-谷氨酰基键的水解和随后的生色剂对硝基苯胺（PNA）的释放中起着关键作用。[2]
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
Paul L Feingold et al.
Molecular cancer therapeutics, 17(9), 2013-2023 (2018-06-24)
In 2017, an estimated 17,000 individuals were diagnosed with esophageal adenocarcinoma (EAC), and less than 20% will survive 5 years. Positron emission tomography avidity is indicative of high glucose utilization and is nearly universal in EAC. TXNIP blocks glucose uptake
Alessandro Corti et al.
Scientific reports, 9(1), 891-891 (2019-01-31)
L-γ-Glutamyl-p-nitroanilide (GPNA) is widely used to inhibit the glutamine (Gln) transporter ASCT2, but recent studies have demonstrated that it is also able to inhibit other sodium-dependent and independent amino acid transporters. Moreover, GPNA is a well known substrate of the
Alessandro Corti et al.
Scientific reports, 9(1), 891-891 (2019-01-31)
L-γ-Glutamyl-p-nitroanilide (GPNA) is widely used to inhibit the glutamine (Gln) transporter ASCT2, but recent studies have demonstrated that it is also able to inhibit other sodium-dependent and independent amino acid transporters. Moreover, GPNA is a well known substrate of the
Karol Dokladny et al.
Metabolites, 11(12) (2021-12-24)
Colonic epithelium-commensal interactions play a very important role in human health and disease development. Colonic mucus serves as an ecologic niche for a myriad of commensals and provides a physical barrier between the epithelium and luminal content, suggesting that communication
Lucía Trilla-Fuertes et al.
BMC cancer, 20(1), 307-307 (2020-04-16)
Metabolomics has a great potential in the development of new biomarkers in cancer and it has experiment recent technical advances. In this study, metabolomics and gene expression data from 67 localized (stage I to IIIB) breast cancer tumor samples were
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