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Merck

SAB3500576

抗-MFSD2A 兔抗

affinity isolated antibody, buffered aqueous solution

别名:

抗-mfsd2aa, 抗-主要促进子超家族含结构域蛋白2A

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选择尺寸

100 μG

$475.80

$475.80

目录价$793.00节省 40%

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关于此项目

NACRES:
NA.41
UNSPSC Code:
12352203

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产品名称

抗-MFSD2A 兔抗, affinity isolated antibody, buffered aqueous solution

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

mouse, rat, human

technique(s)

immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

Gene Information

zebrafish ... mfsd2aa(492810)

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此商品
SAB2900890HPA043107SAB3500577
Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

rabbit

technique(s)

immunofluorescence: suitable, indirect ELISA: suitable, immunohistochemistry: suitable, western blot: suitable

technique(s)

immunofluorescence: 20 μg/mL, immunohistochemistry: 5 μg/mL, western blot: 1-2 μg/mL (Recombinant Protein)

technique(s)

immunofluorescence: 0.25-2 μg/mL, immunohistochemistry: 1:20-1:50

technique(s)

indirect ELISA: suitable, western blot: suitable

clone

polyclonal

clone

polyclonal

clone

polyclonal

clone

polyclonal

Biochem/physiol Actions

包含2a(Mfsd2a)的主要促进子超家族结构域充当必需的omega-3脂肪酸二十二碳六烯酸的转运蛋白。它对于出生后大脑的生长在血脑屏障中至关重要。如果该基因存在遗传变异,则观察到从胚胎期到成年期的血脑屏障渗漏。MFSD2A基因突变导致小头畸形和心室肥大。

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

Features and Benefits

完放心地使用我们的抗体。如果抗体在您的申请的研究中不起作用,我们将全额退款或安排替代抗体。了解更多信息。

General description

含有2a(Mfsd2a)的主要促进子超家族结构域是钠依赖性溶血磷脂酰胆碱(LPC)转运蛋白。血脑屏障中微血管的内皮表达高水平的Mfsd2a。

Immunogen

MFSD2A抗体通过靶向人MFSD2A羧基末端附近的18个氨基酸多肽获得。

Other Notes

可以使用阻断肽SBP3500576阻断该抗体的作用。

Physical form

以含有0.02%叠氮化钠的PBS形式提供。

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存储类别

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Mfsd2a is critical for the formation and function of the blood-brain barrier
Ben-ZA, et al.
Nature, 507-511 (2014)
The lysolipid transporter Mfsd2a regulates lipogenesis in the developing brain
Chan JP, et al.
PLoS Biology, 16(8), e2006443-e2006443 (2018)
Inactivating Mutations in MFSD2A, Required for Omega-3 Fatty Acid Transport in Brain, Cause a Lethal Microcephaly Syndrome
Guemez-GA, et al.
Nature Genetics, 47(7), 809-809 (2015)
Takuro Iwao et al.
PloS one, 18(2), e0281946-e0281946 (2023-02-17)
Nutrients are actively taken up by the brain via various transporters at the blood-brain barrier (BBB). A lack of specific nutrients in the aged brain, including decreased levels of docosahexaenoic acid (DHA), is associated with memory and cognitive dysfunction. To
Long N Nguyen et al.
Nature, 509(7501), 503-506 (2014-05-16)
Docosahexaenoic acid (DHA) is an omega-3 fatty acid that is essential for normal brain growth and cognitive function. Consistent with its importance in the brain, DHA is highly enriched in brain phospholipids. Despite being an abundant fatty acid in brain

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