SRP5248

PDHK2, active, GST tagged human

Name: PDHK2, active, GST tagged human
Brand: SIGMA

PRECISIO^® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

别名:

PDK2

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关于此项目

分類程式碼代碼:

12352200

NACRES:

NA.32

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生物源

human

重組細胞

expressed in baculovirus infected Sf9 cells

產品線

PRECISIO^® Kinase

化驗

≥70% (SDS-PAGE)

形狀

buffered aqueous glycerol solution

比活性

6.4-8.6 nmol/min·mg

分子量

~70 kDa

NCBI登錄號

NM_002611

應用

cell analysis

運輸包裝

dry ice

儲存溫度

−70°C

基因資訊

human ... PDK2(5164)

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此商品	SRP5247	SRP5249	SRP5363
Sigma-Aldrich SRP5248 PDHK2, active, GST tagged human	Sigma-Aldrich SRP5247 PDHK1, active, GST tagged human	Sigma-Aldrich SRP5249 PDHK3, active, GST tagged human	Sigma-Aldrich SRP5363 PAK2, GST tagged human
assay ≥70% (SDS-PAGE)	assay ≥70% (SDS-PAGE)	assay ≥70% (SDS-PAGE)	assay ≥70% (SDS-PAGE)
Gene Information human ... PDK2(5164)	Gene Information human ... PDK1(5163)	Gene Information human ... PDK3(5165)	Gene Information human ... PAK2(5062)
specific activity 6.4-8.6 nmol/min·mg	specific activity 1.4-2 nmol/min·mg	specific activity 10.2-13.8 nmol/min·mg	specific activity -
biological source human	biological source human	biological source -	biological source human
form buffered aqueous glycerol solution	form buffered aqueous glycerol solution	form buffered aqueous glycerol solution	form buffered aqueous glycerol solution
application(s) cell analysis	application(s) cell analysis	application(s) -	application(s) cell analysis

生化／生理作用

PDHK2 or Pyruvate Dehydrogenase Kinase 2 is a member of the PDHK family that phosphorylate and inactivate the Pyruvate Dehydrogenase (PDH). PDH is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. PDHK2 is a primary PPARbeta/delta target gene in humans which underlines the importance of PPAR in the control of metabolism. There are two candidate PPAR response elements in the PDHK2 gene.

外觀

Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

準備報告

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

法律資訊

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

10 - Combustible liquids

水污染物質分類（WGK）

WGK 1

閃點（°F）

Not applicable

閃點（°C）

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

N233-1

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Three members of the human pyruvate dehydrogenase kinase gene family are direct targets of the peroxisome proliferator-activated receptor beta/delta.

Tatjana Degenhardt et al.

Journal of molecular biology, 372(2), 341-355 (2007-08-03)

The nuclear receptors peroxisome proliferator-activated receptors (PPARs) are known for their critical role in the metabolic syndrome. Here, we show that they are direct regulators of the family of pyruvate dehydrogenase kinase (PDK) genes, whose products act as metabolic homeostats

Diversity of the pyruvate dehydrogenase kinase gene family in humans.

R Gudi et al.

The Journal of biological chemistry, 270(48), 28989-28994 (1995-12-01)

Recent evidence from this laboratory indicates that at least two isoenzymic forms of pyruvate dehydrogenase kinase (PDK1 and PDK2) may be involved in the regulation of enzymatic activity of mammalian pyruvate dehydrogenase complex by phosphorylation (Popov, K.M., Kedishvili, N.Y., Zhao

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