This product is a racemic mixture of R and S ibuprofen.
I4883
Ibuprofen
≥98% (GC), powder, COX inhibitor
Synonym(s):
2-(4-Isobutylphenyl)propanoic acid, Brufen, Motrin, Rebugen, α-Methyl-4-(isobutyl)phenylacetic acid, (±)-2-(4-Isobutylphenyl)propanoic acid
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About This Item
Empirical Formula (Hill Notation):
C13H18O2
CAS Number:
Molecular Weight:
206.28
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
239-784-6
MDL number:
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Product Name
Ibuprofen, ≥98% (GC)
InChI key
HEFNNWSXXWATRW-UHFFFAOYSA-N
InChI
1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)
SMILES string
CC(C)Cc1ccc(cc1)C(C)C(O)=O
biological source
synthetic (organic)
assay
≥98% (GC)
form
powder
mp
77-78 °C
solubility
ethanol: 50 mg/mL, clear, colorless to faintly yellow
Quality Level
Gene Information
human ... ALB(213), ALOX5(240), CYP1A2(1544), CYP2C9(1559), IL8RA(3577), PTGS1(5742), PTGS2(5743)
mouse ... Alox5(11689)
rat ... Alox5(25290), Ptgs1(24693)
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Related Categories
1 of 4
This Item | I110 | BP539 | I0020000 |
|---|---|---|---|
| assay ≥98% (GC) | assay ≥98% (HPLC) | assay - | assay - |
| form powder | form - | form crystalline | form - |
| Quality Level 100 | Quality Level 100 | Quality Level - | Quality Level - |
| solubility ethanol: 50 mg/mL, clear, colorless to faintly yellow | solubility - | solubility - | solubility - |
| biological source synthetic (organic) | biological source - | biological source - | biological source - |
| mp 77-78 °C | mp - | mp - | mp - |
Application
Ibuprofen has been used:
- to study its vascular and pulmonary effects on neonatal lung development[1]
- to study its effects on cell apoptosis, cell proliferation, and histology changes in human cholangiocarcinoma cell lines[2]
- in the preparation of a terpene-based therapeutic deep eutectic system (THEDES) to investigate its physicochemical, antimicrobial, and anticancer properties[3]
Biochem/physiol Actions
Cyclooxygenase (COX) inhibitor that has greater activity against COX-1 than against COX-2.
General description
Ibuprofen is a commonly used nonsteroidal anti-inflammatory drug (NSAID) known for its pain-relieving, anti-inflammatory, and fever-reducing properties. It can hinder the effectiveness of various antihypertensive medications, including β-adrenergic blockers, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, and diuretics. Ibuprofen exists in an unbound state in cerebrospinal fluid and is accumulated in the synovial fluid of inflamed joints in arthritis patients.[4]
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Untangling the bioactive properties of therapeutic deep eutectic solvents based on natural terpenes
Silva E, et al.
Current research in medicine (2021)
The Effects of Ibuprofen, Naproxen and Diclofenac on cell Apoptosis, Cell Proliferation and Histology Changes in Human Cholangiocarcinoma Cell Lines
Leksomboon R, et al.
Asian Pacific Journal of Cancer Prevention (2022)
PharmGKB summary: ibuprofen pathways
Mazaleuskaya LL, et al.
Pharmacogenetics and Genomics (2015)
Vascular and pulmonary effects of ibuprofen on neonatal lung development
Chen X, et al.
Respiratory Research (2023)
Mateusz P Czub et al.
Journal of medicinal chemistry, 63(13), 6847-6862 (2020-05-30)
Every day, hundreds of millions of people worldwide take nonsteroidal anti-inflammatory drugs (NSAIDs), often in conjunction with multiple other medications. In the bloodstream, NSAIDs are mostly bound to serum albumin (SA). We report the crystal structures of equine serum albumin
Articles
Discover Bioactive Small Molecules for Lipid Signaling Research
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