A6720

N-Acetyl-Trp-Glu-His-Asp-7-amido-4-trifluoromethylcoumarin trifluoroacetate salt

Name: N-Acetyl-Trp-Glu-His-Asp-7-amido-4-trifluoromethylcoumarin trifluoroacetate salt
Brand: SIGMA

≥97% (HPLC), powder

同義詞:

Ac-WEHD-AFC

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關於此項目

NACRES:

NA.77

PubChem Substance ID:

329770902

UNSPSC Code:

12352209

MDL number:

MFCD01862607

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產品名稱

N-Acetyl-Trp-Glu-His-Asp-7-amido-4-trifluoromethylcoumarin trifluoroacetate salt, ≥97% (HPLC), powder

InChI

1S/C38H37F3N8O11/c1-18(50)45-27(10-19-15-43-25-5-3-2-4-22(19)25)36(58)47-26(8-9-31(51)52)34(56)48-28(11-21-16-42-17-44-21)37(59)49-29(14-32(53)54)35(57)46-20-6-7-23-24(38(39,40)41)13-33(55)60-30(23)12-20/h2-7,12-13,15-17,26-29,43H,8-11,14H2,1H3,(H,42,44)(H,45,50)(H,46,57)(H,47,58)(H,48,56)(H,49,59)(H,51,52)(H,53,54)/t26-,27-,28-,29-/m0/s1

SMILES string

CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc3c[nH]cn3)C(=O)N[C@@H](CC(O)=O)C(=O)Nc4ccc5c(OC(=O)C=C5C(F)(F)F)c4

InChI key

NEGOLAGPKZGIKJ-DZUOILHNSA-N

assay

≥97% (HPLC)

form

powder

color

yellow

solubility

DMSO/DMF: 20 mM

storage temp.

−20°C

Quality Level

200

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本產品	A1086	A0466	A9965
Sigma-Aldrich A6720 N-Acetyl-Trp-Glu-His-Asp-7-amido-4-trifluoromethylcoumarin trifluoroacetate salt	Sigma-Aldrich A1086 N-乙酰基-Asp-Glu-Val-Asp-7-酰胺基-4-甲基香豆素	Sigma-Aldrich A0466 N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-trifluoromethylcoumarin	Sigma-Aldrich A9965 N-Acetyl-Tyr-Val-Ala-Asp-7-amido-4-trifluoromethylcoumarin
assay ≥97% (HPLC)	assay ≥97% (HPLC)	assay ≥90% (HPLC)	assay ≥95% (HPLC)
form powder	form powder	form powder	form powder
Quality Level 200	Quality Level 100	Quality Level 200	Quality Level 200
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
solubility DMSO/DMF: 20 mM	solubility DMSO: 10 mM	solubility H₂O: 1 mg/mL	solubility -
color yellow	color white	color white	color white

Biochem/physiol Actions

Fluorogenic substrate for caspase 1 and 5.

Features and Benefits

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

存儲類別/等級

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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分析證明 (COA)

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A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE).

T A Rano et al.

Chemistry & biology, 4(2), 149-155 (1997-02-01)

Interleukin-1beta converting enzyme (ICE/caspase-1) is the protease responsible for interleukin-1beta (IL-1beta) production in monocytes. It was the first member of a new cysteine protease family to be identified. Members of this family have functions in both inflammation and apoptosis. A

Substrate specificities of caspase family proteases.

R V Talanian et al.

The Journal of biological chemistry, 272(15), 9677-9682 (1997-04-11)

The caspase family represents a new class of intracellular cysteine proteases with known or suspected roles in cytokine maturation and apoptosis. These enzymes display a preference for Asp in the P1 position of substrates. To clarify differences in the biological

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