SML2240
IU1-47
≥98% (HPLC)
同義詞:
1-[1-(4-Chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-piperidinyl)ethanone
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選擇尺寸
關於此項目
經驗公式（希爾表示法）:
C19H23ClN2O
CAS 編號:
分子量：:
330.85
UNSPSC Code:
12352200
MDL number:
NACRES:
NA.21
產品名稱
IU1-47, ≥98% (HPLC)
InChI key
VXQIPRWKLACSKZ-UHFFFAOYSA-N
SMILES string
ClC1=CC=C(N2C(C)=CC(C(CN3CCCCC3)=O)=C2C)C=C1
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
IU1-47 is a potent and selective inhibitor of the deubiquitinating enzyme UPS14. IU1-47 enhances protein degradation including human wild-type and pathological Tau forms in neurons.
potent and selective inhibitor of the deubiquitinating enzyme UPS14
存儲類別/等級
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Monica Boselli et al.
The Journal of biological chemistry, 292(47), 19209-19225 (2017-10-04)
The ubiquitin-proteasome system (UPS) is responsible for most selective protein degradation in eukaryotes and regulates numerous cellular processes, including cell cycle control and protein quality control. A component of this system, the deubiquitinating enzyme USP14, associates with the proteasome where
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