MilliporeSigma

AR

androgen receptor

Synonyms:
AIS, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM
Species:
UniProtKB ID:
Gene ID:
  • Human(367) Summary: The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
  • Mouse(11835) androgen receptor
  • Rat(24208) androgen receptor
  • fruit fly(44503) abdomen rotatum
  • Zebrafish(100005148) androgen receptor
  • chicken(422165) androgen receptor
  • dog(403588) androgen receptor
  • domestic cat(101081787) androgen receptor
  • domestic cat(751827) androgen receptor
  • Horse(100033980) androgen receptor
  • cow(280675) androgen receptor
  • sheep(443042) androgen receptor
  • Goat(100860827) androgen receptor
  • Domestic Rabbit(100009193) androgen receptor
  • domestic guinea pig(100726891) androgen receptor

Custom & Knockdown Gene Products

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  • Custom Gene Products

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Small Molecule - Activator

Product Number
Description
Species
α-Estradiol, powder, ≥98% (TLC),
Species
human, rat
19-Norethindrone, ≥98%, powder,
Species
human, rat
Propylene glycol monomethyl ether acetate, ReagentPlus®, ≥99.5%,
Species
human
Resveratrol, ≥99% (HPLC),
Species
human, rat, mouse
Diethylstilbestrol, ≥99% (HPLC),
Species
human, mouse, rat

Small Molecule - Agonist

Product Number
Description
Species
Testosterone enantate, European Pharmacopoeia (EP) Reference Standard,
Species
human
Testosterone, European Pharmacopoeia (EP) Reference Standard,
Species
human
Testosterone cypionate, United States Pharmacopeia (USP) Reference Standard,
Species
human
Oxandrolone, United States Pharmacopeia (USP) Reference Standard,
Species
human
Fluoxymesterone, British Pharmacopoeia (BP) Reference Standard,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
Nilutamide, European Pharmacopoeia (EP) Reference Standard,
Species
human
Bicalutamide for system suitability, European Pharmacopoeia (EP) Reference Standard,
Species
human
Benzophenone, ReagentPlus®, 99%,
Species
rat
4,4′-Dihydroxybenzophenone, 99%,
Species
rat
4-Hydroxybenzophenone, 98%,
Species
rat

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-phospho-AR (pSer213) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
western blot
Anti-AR (Ab-650) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse
Application
western blot
Anti-Androgen Receptor antibody, Rabbit monoclonal, clone SP107, recombinant, expressed in proprietary host, affinity isolated antibody,
Species Reactivity
dog, human, mouse, pig, rat
Application
immunohistochemistry
Monoclonal Anti-AR antibody produced in mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL9255, purified immunoglobulin, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
Anti-phospho-Androgen Receptor (Ser81) Antibody, rabbit monoclonal, culture supernatant, Upstate®,
Species Reactivity
human
Application
western blot

Small Molecule - Blocker

Product Number
Description
Species
Flutamide, ,
Species
mouse, rat, human

Small Molecule - Inhibitor

Product Number
Description
Species
trans-Chalcone, 97%,
Species
rat, human
Galeterone, ≥98% (HPLC),
Species
human
4-(Benzyloxy)phenol, 98%,
Species
rat, human
Spironolactone, 97.0-103.0%,
Species
rat, human
Testosterone propionate, solid,
Species
human, rat

Small Molecule - Ligand

Product Number
Description
Species
Testosterone, VETRANAL®, analytical standard,
Species
human
4-Hydroxyestradiol, ,
Species
rat, human
Tamoxifen, ≥99%,
Species
human, rat
Testosterone, ≥98%,
Species
mouse, human, rat
Progesterone, powder, BioReagent, suitable for cell culture,
Species
mouse, human, rat

Proteins

Product Number
Description
Species
Androgen receptor (650-920), human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE),
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Ar,
Species
mouse
MISSION® esiRNA, targeting human AR,
Species
human