MilliporeSigma

CD46

CD46 molecule, complement regulatory protein

Synonyms:
AHUS2, MCP, MIC10, TLX, TRA2.10
Species:
UniProtKB ID:
Gene ID:
  • Human(4179) Summary: The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]
  • Mouse(17221) CD46 antigen, complement regulatory protein
  • Rat(29333) CD46 molecule, complement regulatory protein
  • cow(616002) CD46 molecule, complement regulatory protein
  • cow(280851) CD46 molecule, complement regulatory protein
  • domestic cat(101094152) CD46 molecule, complement regulatory protein
  • naked mole-rat(101704640) CD46 molecule, complement regulatory protein
  • domestic guinea pig(100135498) CD46 antigen, complement regulatory protein
  • dog(609365) CD46 molecule, complement regulatory protein

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

ELISA

Product Number
Description
Species
Human CD46 ELISA, for serum, plasma and cell culture supernatants,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Monoclonal Anti-CD46-FITC antibody produced in mouse, clone MEM-258, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
bovine, human
Application
flow cytometry
Anti-CD46 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
Monoclonal Anti-CD46 antibody produced in mouse, clone 1B6, ascites fluid,
Species Reactivity
human
Application
ELISA
western blot
Anti-CD46 antibody produced in rabbit, ,
Species Reactivity
human
Application
immunohistochemistry
western blot
Anti-Human CD46/TLX (MEM-258) ColorWheel® Dye-Ready mAb, ,
Species Reactivity
human
Application
flow cytometry

Proteins

Product Number
Description
Species
Monkey CD46-BC, His-Tag, recombinant, expressed in HEK 293 cells,
Species
mouse
Monkey CD46-C, His-Tag, recombinant, expressed in HEK 293 cells,
Species
mouse
Human CD46-BC, His-Tag, recombinant, expressed in HEK 293 cells,
Species
human
Human CD46-C, His-Tag, recombinant, expressed in HEK 293 cells,
Species
human
CD46 human, recombinant, expressed in E. coli, ≥85% (SDS-PAGE),
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human CD46,
Species
human