MilliporeSigma

SREBF1

sterol regulatory element binding transcription factor 1

Synonyms:
SREBP-1c, SREBP1, bHLHd1
Species:
UniProtKB ID:
Gene ID:
  • Human(6720) Summary: This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(20787) sterol regulatory element binding transcription factor 1
  • Rat(78968) sterol regulatory element binding transcription factor 1
  • chicken(373915) sterol regulatory element binding transcription factor 1
  • domestic cat(101087535) sterol regulatory element binding transcription factor 1
  • dog(403475) sterol regulatory element binding transcription factor 1
  • Horse(100052283) sterol regulatory element binding transcription factor 1
  • sheep(100329218) sterol regulatory element binding transcription factor 1
  • Goat(100860908) sterol regulatory element binding transcription factor 1
  • cow(539361) sterol regulatory element binding transcription factor 1
  • domestic guinea pig(100731641) sterol regulatory element binding transcription factor 1
  • naked mole-rat(101705277) sterol regulatory element binding transcription factor 1
  • Zebrafish(793274) sterol regulatory element binding transcription factor 1

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-SREBP1 Antibody, clone 2121, clone 2121, Upstate®, from mouse,
Species Reactivity
human
Application
western blot
Anti-SREBP-1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, rat
Application
ELISA
immunohistochemistry

western blot
Anti-SREBP-1 Antibody, clone 2A4, clone 2A4, from mouse,
Species Reactivity
canine, hamster, human
Application
western blot
Anti-SREBF1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
Anti-SREBF1 (AB1) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse
Application
western blot

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Srebf1,
Species
mouse
MISSION® esiRNA, targeting human SREBF1,
Species
human