MilliporeSigma

TP53

tumor protein p53

Synonyms:
BCC7, LFS1, P53, TRP53
Species:
UniProtKB ID:
Gene ID:
  • Human(7157) Summary: This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277). [provided by RefSeq, Feb 2013]
  • Rat(24842) tumor protein p53
  • Domestic Rabbit(100009292) tumor protein p53
  • domestic guinea pig(100379269) tumor protein p53
  • sheep(443421) tumor protein p53
  • cow(281542) tumor protein p53
  • Zebrafish(30590) tumor protein p53
  • naked mole-rat(101701769) tumor protein p53
  • dog(403869) tumor protein p53
  • chicken(396200) tumor protein p53
  • Horse(100062044) tumor protein p53
  • domestic cat(493847) tumor protein p53

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ELISA

Product Number
Description
Species
Rat Tp53 / Cellular Tumor Antigen p53 ELISA Kit, ,
Species
rat
Human p53 ELISA Kit, for serum, plasma, cell culture supernatant and urine,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-p53 antibody, Mouse monoclonal, clone BP53-12, ascites fluid,
Species Reactivity
human
Application
ELISA
immunocytochemistry

immunohistochemistry

immunoprecipitation (IP)

microarray

western blot
Anti-p53 antibody, Mouse monoclonal, clone PAb1801, purified from hybridoma cell culture,
Species Reactivity
human
Application
ELISA
immunohistochemistry

immunoprecipitation (IP)

western blot
Monoclonal Anti-p53−Biotin antibody produced in mouse, ~1 mg/mL, clone DO-1, ascites fluid, buffered aqueous solution,
Species Reactivity
human
Application
flow cytometry
immunocytochemistry

immunohistochemistry

immunoprecipitation (IP)

western blot
Anti-p53 (Acetyl-Lys317), C-Terminal antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence

western blot
Anti-TP53 (Ab-315) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
western blot

Cell Lines

Product Number
Description
Species
SW48 Cells TP53 -/-, ,
Species
human
MCF10A CELLS TP53 (-/-), ,
Species
human
DLD1 Cells TP53 -/-, ,
Species
human

Small Molecule - Inhibitor

Product Number
Description
Species
CP-31398 dihydrochloride hydrate, ≥98% (HPLC),
Species
mouse, rat, human

Proteins

Product Number
Description
Species
p53 human, recombinant, expressed in baculovirus infected Sf21 cells,
Species
human
p53 human, recombinant, expressed in E. coli, buffered aqueous glycerol solution,
Species
human
p53 (1-363) C-terminal deletion human, recombinant, expressed in insect cells, ≥80% (SDS-PAGE),
Species
human
p53 (1-342) C-terminal deletion human, recombinant, expressed in insect cells, ≥80% (SDS-PAGE),
Species
human
p53 (1-81), wild type, GST tagged human, recombinant, expressed in E. coli, ≥80% (SDS-PAGE),
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human TP53,
Species
human