This product contains < 1.0 EU/ug of the enzyme.
M8945
Matrix Metalloproteinase-9 human
recombinant, >90% (SDS-PAGE), buffered aqueous solution
Synonym(s):
Gelantinase-B, Gelatinase, 95 kDa, MMP-9
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Product Name
Matrix Metalloproteinase-9 human, recombinant, >90% (SDS-PAGE), buffered aqueous solution
Quality Level
assay
>90% (SDS-PAGE)
form
buffered aqueous solution
mol wt
apparent mol wt ~93 kDa
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... MMP9(4318)
1 of 4
This Item | SAE0077 | SAE0078 | M9070 |
|---|---|---|---|
| assay >90% (SDS-PAGE) | assay 95% (SDS-PAGE) | assay ≥95% (SDS-PAGE) | assay >90% (SDS-PAGE) |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| form buffered aqueous solution | form liquid | form liquid | form lyophilized powder |
| shipped in dry ice | shipped in dry ice | shipped in dry ice | shipped in - |
| mol wt apparent mol wt ~93 kDa | mol wt calculated mol wt 76 kDa, observed mol wt 92 kDa (The protein migrates as a 92 kDa protein on SDS-PAGE due to glycosylation) | mol wt calculated mol wt 66 kDa, observed mol wt 82 kDa by SDS-PAGE (The protein migrates as a 82 kDa protein on SDS-PAGE due to glycosylation) | mol wt apparent mol wt ~69 kDa |
| UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. |
Analysis Note
The biological activity is measured by its ability to cleave a fluorogenic peptide substrate.
Biochem/physiol Actions
MMP-9 degrades the collagens that make up the extracellular matrix, which has a role in the control of angiogenesis.
Physical form
Solution in Tris-HCl, pH 7.5, Calcium Chloride, Sodium Chloride, and Brij-35
Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Gelatinase B
Collier, I.E., and Goldberg, G.I. et al.
Handbook of Proteolytic Enzymes, 1205-1210 (1998)
Carla Graça et al.
Foods (Basel, Switzerland), 9(10) (2020-10-07)
The influence of flour replacement by yogurt or curd-cheese additions (from 10% to 20%, w/w) on the glycemic response and bioactivity improvements of gluten-free bread was evaluated. Starch digestibility, measured by an in vitro digestion model, was applied to determine
S Chandler et al.
Neuroscience letters, 201(3), 223-226 (1995-12-15)
Matrix metalloproteinases (MMPs) are a group of enzymes responsible for the degradation of interstitial connective tissue and basement membrane. The coding sequences for five of the human MMPs, viz. interstitial collagenase, 72 kDa gelatinase, stromelysin-1, matrilysin and 92 kDa gelatinase
Tomoaki Fukui et al.
Biochemical and biophysical research communications, 460(3), 741-746 (2015-03-31)
Non-destructive detection of cartilage-degrading activities represents an advance in osteoarthritis (OA) research, with implications in studies of OA pathogenesis, progression, and intervention strategies. Matrix metalloproteinases (MMPs) are principal cartilage degrading enzymes that contribute to OA pathogenesis. MMPSense750 is an in-vivo
Narjes Khatoun Shabani Sadr et al.
Biochemical genetics, 58(6), 883-900 (2020-07-02)
Sialic acid (N-acetylneuraminic acid, NANA) is found at all cell surfaces of vertebrates. Although it is widely accepted that sialic acid is an essential substrate for brain development via a significant role in nerve transfers, structure of glycosides, and synaptogenesis
Related Content
Instructions
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Is product M8945 (Marix Metalloproteinase-9 Human) endotoxin free?
1 answer-
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Does product M8945 (Matrix Metalloproteinase-9 Human) need to be activated?
1 answer-
To activate recombinant human MMP-9, prepare a p-aminophenylmercuric acetate (APMA) solution in DMSO. Add the AMPA solution to the MMP-9 to a final APMA concentration of 1 mM. Incubate at 37°C. for 16 - 24 hours.
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What is the molecular weight of product M8945 (Matrix Metalloproteinase-9 Human)
1 answer-
Human MMP-9 consists of a 688 amino acid residue recombinant protein which has a predicted molecular mass of approximately 77 kDa. By SDS-PAGE the apparent molecular mass is approximately 93 kDa.
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