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MilliporeSigma

T-073

L-Tiroxina

100 μg/mL in methanol with 0.1N NH3, ampule of 1 mL, certified reference material, Cerilliant®

Sinónimos:

3,3′,5,5″-Tetrayodo-L-tironina, 3-[4-(4-Hidroxi-3,5-diyodofenoxi)-3,5-diyodofenil]-L-alanina, T4

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1 ML

$73.65

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Fórmula lineal:
HOC6H2(I)2OC6H2(I)2CH2CH(NH2)CO2H
Número CAS:
51-48-9
Peso molecular:
776.87
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329826617
MDL number:
MFCD00002595
Beilstein/REAXYS Number:
2228515

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Nombre del producto

L-Tiroxina, 100 μg/mL in methanol with 0.1N NH3, ampule of 1 mL, certified reference material, Cerilliant®

InChI key

XUIIKFGFIJCVMT-LBPRGKRZSA-N

SMILES string

N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O

InChI

1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1

grade

certified reference material

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

100 μg/mL in methanol with 0.1N NH3

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

mp

223 °C (dec.) (lit.)

application(s)

clinical testing
clinical testing

format

single component solution

storage temp.

−20°C

Quality Level

300

Gene Information

human ... THRA(7067), THRB(7068)

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1 of 4

Este artículo
T-074T1775T-076
L-Tiroxina 100 μg/mL in methanol with 0.1N NH3, ampule of 1 mL, certified reference material, Cerilliant®

Supelco

T-073

L-Tiroxina

3,3′,5-Triyodo-L-tironina 100 μg/mL in methanol with 0.1N NH3, ampule of 1 mL, certified reference material, Cerilliant®

Supelco

T-074

3,3′,5-Triyodo-L-tironina

L-Tiroxina powder, BioReagent, suitable for cell culture

Sigma-Aldrich

T1775

L-Tiroxina

L-Thyroxine-13C6 solution 100 μg/mL in methanol with 0.1N NH3, ampule of 1 mL, certified reference material, Cerilliant®

Supelco

T-076

L-Thyroxine-13C6 solution

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

application(s)

clinical testing
clinical testing

application(s)

clinical testing
clinical testing

application(s)

-

application(s)

clinical testing

form

liquid

form

liquid

form

powder

form

liquid

format

single component solution

format

single component solution

format

-

format

single component solution

Quality Level

300

Quality Level

300

Quality Level

200

Quality Level

300

grade

certified reference material

grade

certified reference material

grade

-

grade

certified reference material

Biochem/physiol Actions

La L-tiroxina (T4) y la triyodo-L-tironina (T3) son hormonas que contienen yodo producidas a partir de la tiroglobulina en las células foliculares tiroideas. La estimulación de la tasa metabólica y la regulación del crecimiento y el desarrollo por esas hormonas parece deberse a sus efectos sobre la transcripción del ADN y, por tanto, la síntesis de proteínas.

General description

Thyroxine or T4 is a thyroid hormone responsible for regulation of the body′s basal metabolic rate and essential for growth, development and heart and nervous system function. Free and total T4 serum levels are measured by LC-MS/MS for determination of hyper- or hypothyroidism as well as for monitoring treatment with synthetic thyroid hormones. Certified Spiking Solutions® are suitable for use in LC-MS/MS testing methods as starting materials in preparation of linearity standards, calibrators, and controls.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTIONS is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Chronic 3 - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes,Central nervous system

Clase de almacenamiento

3 - Flammable liquids

wgk

WGK 2

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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R L Sutherland et al.
The Journal of endocrinology, 65(3), 319-332 (1975-06-01)
A competitive binding technique is described for the estimation of the thyroxine (T4)-binding properties of serum proteins in dilute blood serum and lymph. When used in conjunction with an assay for total T4 the following parameters can be estimated: the
Sonja Heyerdahl et al.
Thyroid : official journal of the American Thyroid Association, 13(11), 1029-1038 (2003-12-04)
Neonatal screening programs for congenital hypothyroidism (CH) were initiated in the 1970s to ensure early treatment in order to prevent mental retardation. With screening, developmental prognosis is considerably improved, but follow-up studies still report developmental delay compared to controls. To
Ihor Hrytsiuk et al.
Archives of pediatrics & adolescent medicine, 156(5), 485-491 (2002-05-01)
To determine the effect of levothyroxine sodium starting dose on cognitive development, growth, or behavior in children with congenital hypothyroidism identified by neonatal screening. Systematic review of cohort studies. Two analyses were performed: a between-study comparison of mean starting dose
L Ashley Watson et al.
The Journal of clinical investigation, 123(5), 2049-2063 (2013-04-09)
Human ATRX mutations are associated with cognitive deficits, developmental abnormalities, and cancer. We show that the Atrx-null embryonic mouse brain accumulates replicative damage at telomeres and pericentromeric heterochromatin, which is exacerbated by loss of p53 and linked to ATM activation.
Aleid G van Wassenaer et al.
Clinical endocrinology, 56(5), 621-627 (2002-05-29)
Thyroid hormone is crucial for brain development during foetal and neonatal life. In very preterm infants, transient low levels of plasma T4 and T3 are commonly found, a phenomenon referred to as transient hypothyroxinaemia of prematurity. We investigated whether breast
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Simultaneous Determination of Free T3 and Free T4 in Serum

Determination of free thyroid hormones (T3 & T4) in serum by LC-MS/MS following a streamlined 1-hour BioSPME sample preparation.

Protocolos

Online SPE/LC-MS Method for the Rapid Analysis of Thyroid Hormones in Plasma

Determination of the thyroid hormones T4, T3 and rT3 from plasma using an Ascentis Express RP-Amide cartridge to trap the analytes, and a Phenyl-Hexyl column to resolve them.

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