14-627-M

EGFR (L861Q) Protein, active, 10 µg

Name: EGFR (L861Q) Protein, active, 10 µg
Brand: MM
Price: 503 USD

Active, N-terminal GST-tagged, recombinant human EGF Receptor, amino acids 696-end containing the mutation L861Q, for use in Enzyme Assays.

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10 μG

$503.00

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UNSPSC Code:

12352202

eCl@ss:

32160405

NACRES:

NA.32

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biological source

human

Quality Level

100
300

recombinant

expressed in baculovirus infected Sf21 cells

mol wt

M_w 85.8 kDa

manufacturer/tradename

Upstate^®

technique(s)

activity assay: suitable

NCBI accession no.

NM_005228.3
NM_201282.1
NM_201283.1
NM_201284.1

UniProt accession no.

P00533

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Este artículo	14-626-M	14-721-M	14-725-M
Sigma-Aldrich 14-627-M EGFR (L861Q) Protein, active, 10 µg	Sigma-Aldrich 14-626-M EGFR (L858R) Protein, active, 10 µg	Sigma-Aldrich 14-721-M EGFR (T790M, L858R) Protein, active, 10 µg	Sigma-Aldrich 14-725-M EGFR (T790M) Protein, active, 10 µg
biological source human	biological source human	biological source human	biological source human
recombinant expressed in baculovirus infected Sf21 cells	recombinant expressed in baculovirus infected Sf21 cells	recombinant expressed in baculovirus infected Sf21 cells	recombinant expressed in baculovirus infected Sf21 cells
technique(s) activity assay: suitable	technique(s) activity assay: suitable	technique(s) activity assay: suitable	technique(s) activity assay: suitable
mol wt M_w 85.8 kDa	mol wt M_w 85.8 kDa	mol wt M_w 85.8 kDa	mol wt M_w 86 kDa
UniProt accession no. P00533	UniProt accession no. P00533	UniProt accession no. P00533	UniProt accession no. P00533
Quality Level 100, 300	Quality Level 100	Quality Level 100	Quality Level 100, 300

General description

N-terminal GST-tagged, recombinant human EGF Receptor, amino acids 696-end containing the mutation L861Q

Product Source: baculovirus in Sf21 insect cells

Application

Research Category
Inflammation & Immunology

Biochem/physiol Actions

Protein Target: EGFR

Target Sub-Family: TK

Physical form

Glutathione-agarose

Preparation Note

6 months at -70°C

Analysis Note

routinely evaluated by phosphorylation of 0.1mg/ml Poly (Glu4-Tyr)

Other Notes

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Pictograms

GHS07

signalword

Warning

hcodes

H317

pcodes

P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364

Hazard Classifications

Skin Sens. 1

Clase de almacenamiento

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib.

Thomas J Lynch et al.

The New England journal of medicine, 350(21), 2129-2139 (2004-05-01)

Most patients with non-small-cell lung cancer have no response to the tyrosine kinase inhibitor gefitinib, which targets the epidermal growth factor receptor (EGFR). However, about 10 percent of patients have a rapid and often dramatic clinical response. The molecular mechanisms

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