AB5449

Anti-Tropomyosin 4 Antibody

Name: Anti-Tropomyosin 4 Antibody
Brand: MM
Price: 476 USD

serum, Chemicon^®

Sinónimos:

Tm4

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100 μL

$476.00

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UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

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Nombre del producto

Anti-Tropomyosin 4 Antibody, serum, Chemicon^®

biological source

rabbit

conjugate

unconjugated

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human, mouse, rat

manufacturer/tradename

Chemicon^®

technique(s)

immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

NM_003290.1

UniProt accession no.

P67936

shipped in

dry ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... TPM4(7171)

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Este artículo	SAB1304880	ABT189	AB5441
Sigma-Aldrich AB5449 Anti-Tropomyosin 4 Antibody	$ANTI-TPM4 (N-TERM) antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution$ Sigma-Aldrich SAB1304880 ANTI-TPM4 (N-TERM) antibody produced in rabbit	Sigma-Aldrich ABT189 Anti-Tropomyosin 4 Antibody	Sigma-Aldrich AB5441 Anti-Tropomyosin Antibody
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
antibody form serum	antibody form IgG fraction of antiserum	antibody form affinity isolated antibody	antibody form affinity purified immunoglobulin
biological source rabbit	biological source rabbit	biological source rabbit	biological source sheep
clone polyclonal	clone polyclonal	clone polyclonal	clone polyclonal
UniProt accession no. P67936	UniProt accession no. P67936	UniProt accession no. P67936	UniProt accession no. P09493
Gene Information human ... TPM4(7171)	Gene Information human ... TPM4(7171)	Gene Information human ... TPM4(7171)	Gene Information rat ... Tpm3(117557)

Application

Detect Tropomyosin 4 using this Anti-Tropomyosin 4 Antibody validated for use in WB, IC, IH.

Biochem/physiol Actions

Recognizes Tropomyosin 4.

Immunogen

Synthetic peptide corresponding to the 9d exon from the delta gene of tropomyosin.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Transcriptional and proteomic profiling in a cellular model of DYT1 dystonia.

J N Martin et al.

Neuroscience, 164(2), 563-572 (2009-08-12)

DYT1, the most common inherited dystonia, is caused by a common dominant mutation in the TOR1A gene that leads to a glutamic acid deletion in the protein torsinA. Wild-type torsinA locates preferentially in the endoplasmic reticulum while the disease-linked mutant

Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia.

Irina Pleines et al.

The Journal of clinical investigation, 127(3), 814-829 (2017-01-31)

Platelets are anuclear cells that are essential for blood clotting. They are produced by large polyploid precursor cells called megakaryocytes. Previous genome-wide association studies in nearly 70,000 individuals indicated that single nucleotide variants (SNVs) in the gene encoding the actin

Parallel assembly of actin and tropomyosin, but not myosin II, during de novo actin filament formation in live mice.

Andrius Masedunskas et al.

Journal of cell science, 131(6) (2018-03-01)

Many actin filaments in animal cells are co-polymers of actin and tropomyosin. In many cases, non-muscle myosin II associates with these co-polymers to establish a contractile network. However, the temporal relationship of these three proteins in the de novo assembly

Cytoplasmic gamma-actin and tropomodulin isoforms link to the sarcoplasmic reticulum in skeletal muscle fibers.

David S Gokhin et al.

The Journal of cell biology, 194(1), 105-120 (2011-07-06)

The sarcoplasmic reticulum (SR) serves as the Ca(2+) reservoir for muscle contraction. Tropomodulins (Tmods) cap filamentous actin (F-actin) pointed ends, bind tropomyosins (Tms), and regulate F-actin organization. In this paper, we use a genetic targeting approach to examine the effect

Variants in exons 5 and 6 of ACTB cause syndromic thrombocytopenia.

Sharissa L Latham et al.

Nature communications, 9(1), 4250-4250 (2018-10-14)

Germline mutations in the ubiquitously expressed ACTB, which encodes β-cytoplasmic actin (CYA), are almost exclusively associated with Baraitser-Winter Cerebrofrontofacial syndrome (BWCFF). Here, we report six patients with previously undescribed heterozygous variants clustered in the 3'-coding region of ACTB. Patients present

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