H6878

8-Hydroxyquinoline

Name: 8-Hydroxyquinoline
Brand: SIAL

Sinónimos:

8-Quinolinol

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Fórmula empírica (notación de Hill):

C₉H₇NO

Número CAS:

148-24-3

Peso molecular:

145.16

UNSPSC Code:

12352005

NACRES:

NA.21

PubChem Substance ID:

24895771

EC Number:

205-711-1

Beilstein/REAXYS Number:

114512

MDL number:

MFCD00006807

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InChI key

MCJGNVYPOGVAJF-UHFFFAOYSA-N

InChI

1S/C9H7NO/c11-8-5-1-3-7-4-2-6-10-9(7)8/h1-6,11H

SMILES string

Oc1cccc2cccnc12

assay

≥98.5%

form

powder

mp

72.5-74.0 °C

antibiotic activity spectrum

fungi

mode of action

DNA synthesis | interferes
enzyme | inhibits

Quality Level

200

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Este artículo	1.07098	13-2510	36524
Sigma-Aldrich H6878 8-Hydroxyquinoline	Supelco 1.07098 8-Hydroxyquinoline	Sigma-Aldrich 13-2510 8-Quinolinol	Supelco 36524 8-Quinolinol
mode of action DNA synthesis \| interferes, enzyme \| inhibits	mode of action -	mode of action DNA synthesis \| interferes, enzyme \| inhibits	mode of action DNA synthesis \| interferes, enzyme \| inhibits
antibiotic activity spectrum fungi	antibiotic activity spectrum -	antibiotic activity spectrum fungi	antibiotic activity spectrum fungi
Quality Level 200	Quality Level 200	Quality Level -	Quality Level 100
form powder	form solid	form solid	form -
assay ≥98.5%	assay -	assay ≥99.0%	assay 98-100% (GC)
mp 72.5-74.0 °C	mp 72.5-74.0 °C	mp 72.5-74.0 °C	mp 72.5-74.0 °C

Application

Used as a lipophilic monoprotic bidentate chelating agent.

General description

Chemical structure: quinolone

pictograms

GHS06,GHS08,GHS05,GHS09

signalword

Danger

hcodes

H301,H317,H318,H360D,H410

pcodes

P202 - P273 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Repr. 1B - Skin Sens. 1

Clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number

0000463312

0000463311

0000438824

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Generalized enzymatic mechanism of catalysis by tetrameric L-asparaginases from mesophilic bacteria.

Pawel Strzelczyk et al.

Scientific reports, 10(1), 17516-17516 (2020-10-17)

The mechanism of catalysis by the L-glutaminase-asparaginase from Pseudomonas 7A (PGA) was investigated using structural, mass spectrometry, and kinetic data. We had previously proposed mechanism of hydrolysis of L-Asn by the type II L-asparaginase from E. coli (EcAII), but that

Type I Interferon Response Dysregulates Host Iron Homeostasis and Enhances Candida glabrata Infection.

Michael Riedelberger et al.

Cell host & microbe, 27(3), 454-466 (2020-02-23)

Type I interferons (IFNs-I) fulfil multiple protective functions during pathogenic infections, but they can also cause detrimental effects and enhance immunopathology. Here, we report that IFNs-I promote the dysregulation of iron homeostasis in macrophages during systemic infections with the intracellular

Novel tacrine-8-hydroxyquinoline hybrids as multifunctional agents for the treatment of Alzheimer's disease, with neuroprotective, cholinergic, antioxidant, and copper-complexing properties.

María Isabel Fernández-Bachiller et al.

Journal of medicinal chemistry, 53(13), 4927-4937 (2010-06-16)

Tacrine and PBT2 (an 8-hydroxyquinoline derivative) are well-known drugs that inhibit cholinesterases and decrease beta-amyloid (Abeta) levels by complexation of redox-active metals, respectively. In this work, novel tacrine-8-hydroxyquinoline hybrids have been designed, synthesized, and evaluated as potential multifunctional drugs for

Copper-dependent cytotoxicity of 8-hydroxyquinoline derivatives correlates with their hydrophobicity and does not require caspase activation.

Saverio Tardito et al.

Journal of medicinal chemistry, 55(23), 10448-10459 (2012-11-23)

This study reports the structure-activity relationship of a series of 8-hydroxoquinoline derivatives (8-HQs) and focuses on the cytotoxic activity of 5-Cl-7-I-8-HQ (clioquinol, CQ) copper complex (Cu(CQ)). 8-HQs alone cause a dose-dependent loss of viability of the human tumor HeLa and

Targeting of 111In-labeled dendritic cell human vaccines improved by reducing number of cells.

Erik H J G Aarntzen et al.

Clinical cancer research : an official journal of the American Association for Cancer Research, 19(6), 1525-1533 (2013-02-06)

Anticancer dendritic cell (DC) vaccines require the DCs to relocate to lymph nodes (LN) to trigger immune responses. However, these migration rates are typically very poor. Improving the targeting of ex vivo generated DCs to LNs might increase vaccine efficacy

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