M6751

5-Methylcytosine hydrochloride

Name: 5-Methylcytosine hydrochloride
Brand: SIGMA
Price: 169 USD
Availability: InStock

≥99%, synthetic (organic), crystalline powder

Sinónimos:

4-Amino-2-hydroxy-5-methylpyrimidine

Slide 1 of 3

Iniciar sesión para ver los precios por organización y contrato.

Seleccione un Tamaño

250 MG

$169.00

1 G

$508.00

$169.00

Disponible para enviar HOYDetalles

One Time Order

Las suscripciones no están disponibles actualmente.

Acerca de este artículo

Fórmula empírica (notación de Hill):

C₅H₇N₃O · HCl

Número CAS:

58366-64-6

Peso molecular:

161.59

NACRES:

NA.51

PubChem Substance ID:

24897110

UNSPSC Code:

41106305

EC Number:

261-223-9

MDL number:

MFCD11053426

Documentos clave

Ver Toda la documentación

Saltar a

Servicio técnico

¿Necesita ayuda? Nuestro equipo de científicos experimentados está aquí para ayudarle.

Permítanos ayudarle

Nombre del producto

5-Methylcytosine hydrochloride, ≥99%

InChI key

ANWMULVRPAUPJT-UHFFFAOYSA-N

InChI

1S/C5H7N3O.ClH/c1-3-2-7-5(9)8-4(3)6;/h2H,1H3,(H3,6,7,8,9);1H

SMILES string

O=C1NC(N)=C(C)C=N1.[H]Cl

biological source

synthetic (organic)

assay

≥99%

form

crystalline powder

solubility

water: 50 mg/mL, clear to slightly hazy, colorless

Quality Level

300

¿Está buscando productos similares? Visita Guía de comparación de productos

Categorías relacionadas

Biochemicals

Nucleosides and Nucleotides

Comparar elementos similares

Ver comparación completa

Mostrar Diferencias

1 of 4

Este artículo	C3506	I6875	284769
Sigma-Aldrich M6751 5-Methylcytosine hydrochloride	Sigma-Aldrich C3506 Cytosine	Sigma-Aldrich I6875 5-Iodocytosine	Sigma-Aldrich 284769 6-Methylpyridine-3-carboxamide
biological source synthetic (organic)	biological source synthetic (organic)	biological source synthetic (organic)	biological source -
Quality Level 200, 300	Quality Level 200	Quality Level 200	Quality Level 100
assay ≥99%	assay ≥99%	assay ≥99% (TLC)	assay 98%
form crystalline powder	form powder	form powder	form -
solubility water: 50 mg/mL, clear to slightly hazy, colorless	solubility 0.5 M HCl: 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow	solubility formic acid: 50 mg/mL	solubility water: soluble 50 mg/mL, clear to slightly hazy, colorless to light yellow

Application

5-Methylcytosine hydrochloride has been used as standard in high performance liquid chromatography (HPLC) for the estimation of global methylation rates.[1] It has also been used in high-resolution mass spectroscopic analysis.[2]

5-Methylcytosine is used in studies of DNA methylation processes (epigenetics).

Biochem/physiol Actions

5-Methylcytosine mediates gene expression, genomic imprinting and inhibition of transposable elements.[3] It is closely associated with translational fidelity and tRNA recognition.[4]

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Elija entre una de las versiones más recientes:

Certificados de análisis (COA)

Lot/Batch Number

¿No ve la versión correcta?

Si necesita una versión concreta, puede buscar un certificado específico por el número de lote.

Busque por un COA

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Crystal structures of B-DNA dodecamer containing the epigenetic modifications 5-hydroxymethylcytosine or 5-methylcytosine.

Daniel Renciuk et al.

Nucleic acids research, 41(21), 9891-9900 (2013-08-22)

5-Hydroxymethylcytosine (5-hmC) was recently identified as a relatively frequent base in eukaryotic genomes. Its physiological function is still unclear, but it is supposed to serve as an intermediate in DNA de novo demethylation. Using X-ray diffraction, we solved five structures

Absolute quantification of RNA or DNA using acid hydrolysis and mass spectrometry

Lowenthal MS, et al.

Analytical Chemistry, 6, 824-824 (2019)

Widespread occurrence of 5-methylcytosine in human coding and non-coding RNA

Squires JE, et al.

Nucleic Acids Research, 40(11), 5023-5033 (2012)

TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS.

Rachel Deplus et al.

The EMBO journal, 32(5), 645-655 (2013-01-29)

TET proteins convert 5-methylcytosine to 5-hydroxymethylcytosine, an emerging dynamic epigenetic state of DNA that can influence transcription. Evidence has linked TET1 function to epigenetic repression complexes, yet mechanistic information, especially for the TET2 and TET3 proteins, remains limited. Here, we

Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX.

Myunggon Ko et al.

Nature, 497(7447), 122-126 (2013-04-09)

TET (ten-eleven-translocation) proteins are Fe(ii)- and α-ketoglutarate-dependent dioxygenases that modify the methylation status of DNA by successively oxidizing 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxycytosine, potential intermediates in the active erasure of DNA-methylation marks. Here we show that IDAX (also known

Ver todos los artículos relacionados

Questions

Reviews

No rating value

Active Filters

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico

5-Methylcytosine hydrochloride