Salbutamol hemisulfate is not an anticholinergic. This compound is a β2-Adrenergic receptor agonist.
S5013
Salbutamol hemisulfate salt
≥98%
Sinónimos:
α-([t-Butylamino]methyl)-4-hydroxy-m-xylene-α,α′-diol, Albuterol
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Acerca de este artículo
Fórmula lineal:
C13H21NO3 · 1/2H2SO4
Número CAS:
Peso molecular:
288.35
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
256-916-8
MDL number:
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Servicio técnico
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Permítanos ayudarleNombre del producto
Salbutamol hemisulfate salt, ≥98%
InChI
1S/2C13H21NO3.H2O4S/c2*1-13(2,3)14-7-12(17)9-4-5-11(16)10(6-9)8-15;1-5(2,3)4/h2*4-6,12,14-17H,7-8H2,1-3H3;(H2,1,2,3,4)
InChI key
BNPSSFBOAGDEEL-UHFFFAOYSA-N
SMILES string
OS(O)(=O)=O.CC(C)(C)NCC(O)c1ccc(O)c(CO)c1.CC(C)(C)NCC(O)c2ccc(O)c(CO)c2
assay
≥98%
solubility
1 M NaOH: 50 mg/ml, clear to slightly hazy, yellow-green
originator
GlaxoSmithKline
Quality Level
Gene Information
human ... ADRB2(154)
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Categorías relacionadas
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Este artículo | BP302 | PHR1053 | S0150000 |
|---|---|---|---|
| assay ≥98% | assay - | assay - | assay - |
| Quality Level 200 | Quality Level - | Quality Level 300 | Quality Level - |
| solubility 1 M NaOH: 50 mg/ml, clear to slightly hazy, yellow-green | solubility - | solubility - | solubility - |
| originator GlaxoSmithKline | originator - | originator - | originator - |
| Gene Information human ... ADRB2(154) | Gene Information human ... ADRB2(154) | Gene Information human ... ADRB2(154) | Gene Information human ... ADRB2(154) |
Application
Salbutamol hemisulfate salt has been used as reference standards of drugs for the validation of β-agonist residue.[1]
Salbutamol hemisulfate salt was used as standard in analysis of fortified meat for LABA content using ELISA kits.3 It was used to study the response of prostaglandin 2α to various β-adrenergic agonists in cultured bovine endometrial cells.4
Biochem/physiol Actions
β2-Adrenergic receptor agonist.
Salbutamol is a β2 adrenoceptor agonist with short acting bronchodilation and anti-inflammatory effects. It relaxes the airway smooth muscles and inhibits bronchoconstriction induced by adenosine-5′ -monophosphate (AMP). Salbutamol is particularly effective in treatment of asthma as it provides immediate relief. Salbutamol is one of the most popular short-acting BA (SABA). It is useful in treating the symptoms of EIB (exercise induced bronchospasm).[2]
Salbutamol is a β2 adrenoceptor agonist with short acting bronchodilation and anti-inflammatory effects. It relaxes the airway smooth muscles and inhibits bronchoconstriction induced by adenosine-5′ -monophosphate (AMP).1 Salbutamol is particularly effective in treatment of asthma as it provides immediate relief.2
Features and Benefits
This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Warning
hcodes
Hazard Classifications
Carc. 2 - Repr. 2 - Skin Sens. 1
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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R S Pirie et al.
Journal of veterinary pharmacology and therapeutics, 40(3), 231-238 (2016-09-07)
Despite frequent use of metered dose inhalers (MDIs) and spacers in equine practice, limited information exists on the efficiency of aerosol delivery using such devices. We determined the particle size distribution within an MDI-generated salbutamol aerosol delivered via an equine
Medical and pharmacological approach to adjust the salbutamol anti-doping policy in athletes
Pillard F, et al.
Respiratory Research, 16(1), 155-155 (2015)
Validation of ELISA test kits for detection of beta-agonist residues in meat
Ponniah J, et al.
The Southeast Asian Journal of Tropical Medicine and Public Health, 35(1), 481-487 (2004)
R K Dutta et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 142, 112090-112090 (2021-09-01)
MicroRNAs play an important role in health and disease. TGF-β signaling, upregulated by HIV Tat, and in chronic airway diseases and smokers upregulates miR-145-5p to suppress cystic fibrosis transmembrane conductance regulator (CFTR). CFTR suppression in chronic airway diseases like Cystic
Huan Wang et al.
Biosensors & bioelectronics, 49, 14-19 (2013-05-28)
A multiplexed electrochemical biosensor has been developed for fast and sensitive detection of ractopamine (RAC), salbutamol (SAL) and clenbuterol (CLB) based on reduced graphene oxide (rGO) and silver-palladium alloy nanoparticles (AgPd NPs). In this paper, rGO with high conductivity was
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is salbutamol an anticholinergic?
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