SAB6012080

Anti GNE Antibody, clone 23GB5560, Rabbit Monoclonal

clone 23GB5560, recombinant rabbit monoclonal, expressed in HEK293 cells

• Sinónimos: DMRV, GLCNE, IBM2, UAE1
• UNSPSC Code: 12352203

Propiedades

• biological source: rabbit (Monoclonal)
• Quality Level: 100
• recombinant: expressed in HEK 293 cells
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: 23GB5560, recombinant monoclonal
• form: buffered aqueous glycerol solution
• mol wt: 79 kDa
• species reactivity: human
• packaging: vial of 1.5 mL
• enhanced validation: recombinant expression; Learn more about Antibody Enhanced Validation
• sustainability: Greener Alternative Product
• concentration: 0.6 mg/ml
• technique(s): western blot: 1:1,000-1:5,000
• isotype: IgG
• Ensembl | human accession no.: ENSG00000159921
• NCBI accession no.: NP_005467.1
• UniProt accession no.: Q9Y223
• greener alternative category: DfS-Developed
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... GNE(10020)

Descripción

General description

The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

We are committed to bringing you Greener Alternative Products. This product is a Design for Sustainability (DfS) developed product, which belongs to one of the four categories of greener alternatives. Click here to view its DfS scorecard.

Immunogen

A synthesized peptide corresponding to a sequence within amino acids 701-722 of human GNE [NP_005467.1].

Physical form

Solution in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.

Other Notes

Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.