Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
T3077
TRO 19622
≥98% (HPLC), solid
Sinónimos:
NSC 21311, cholest-4-en-3-one, oxime
Iniciar sesión para ver los precios por organización y contrato.
Seleccione un Tamaño
5 MG
$139.40
25 MG
$582.00
$139.40
Precio de catálogo$164.00Ahorre 15 %Disponible para enviar HOYDetalles
Acerca de este artículo
Fórmula empírica (notación de Hill):
C27H45NO
Número CAS:
Peso molecular:
399.65
UNSPSC Code:
12352200
NACRES:
NA.77
Saltar a
Servicio técnico
¿Necesita ayuda? Nuestro equipo de científicos experimentados está aquí para ayudarle.
Permítanos ayudarleNombre del producto
TRO 19622, ≥98% (HPLC), solid
InChI
1S/C27H45NO/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28-29)13-15-26(20,4)25(22)14-16-27(23,24)5/h17-19,22-25,29H,6-16H2,1-5H3/b28-21+
InChI key
QNTASHOAVRSLMD-SGWCAAJKSA-N
assay
≥98% (HPLC)
form
solid
color
white
solubility
DMSO: >10 mg/mL
storage temp.
−20°C
Quality Level
1 of 4
Este artículo | SML1648 | U3633 | O3139 |
|---|---|---|---|
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| form solid | form powder | form powder | form solid |
| Quality Level 100 | Quality Level 100 | Quality Level - | Quality Level 100 |
| storage temp. −20°C | storage temp. −20°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility DMSO: >10 mg/mL | solubility DMSO: 3 mg/mL, clear (warmed) | solubility H2O: 10 mg/mL≥ | solubility DMSO: soluble 13 mg/mL |
| color white | color white to beige | color white to off-white | color - |
Application
TRO 19622 has been used as a mitochondrial permeability transition pore inhibitor in mouse neurons2. TRO 19622 is also known to stimulate myelin repair in rat models of demyelination3.
Biochem/physiol Actions
TRO 19622 can decrease axonal degradation and enhance the rescue of motor nerve conduction in peripheral neuropathy. Furthermore, TRO 19622 can reverse neuropathic pain and tactile allodynia in rat models of diabetes and chemotherapy-induced neuropathic pain4.
TRO19622 ia a neuroprotective agent for motor neurons; candidate therapeutic for amyotrophic lateral sclerosis (ALS).
Preparation Note
TRO 19622 is soluble in DMSO at a concentration that is greater than 10 mg/ml.
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Elija entre una de las versiones más recientes:
¿Ya tiene este producto?
Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Thierry Bordet et al.
The Journal of pharmacology and experimental therapeutics, 322(2), 709-720 (2007-05-15)
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive death of cortical and spinal motor neurons, for which there is no effective treatment. Using a cell-based assay for compounds capable of preventing motor neuron cell death in
Yiqiao Li et al.
The International journal of neuroscience, 123(11), 810-822 (2013-05-15)
Multiple sclerosis is a neurodegenerative autoimmune disease characterized by diffuse oligodendrocyte injury, axonal loss and multifocal demyelination of myelin sheaths in the central nervous system. TRO19622 is a small cholesterol-like compound, which displays remarkable neuroprotective and neuroregenerative properties in neural
Thierry Bordet et al.
The Journal of pharmacology and experimental therapeutics, 326(2), 623-632 (2008-05-22)
Diabetes and cancer chemotherapies are often associated with painful neuropathy. The mechanisms underlying neuropathic pain remain poorly understood, and the current therapies have limited efficacy and are associated with dose-limiting side effects. We recently described the pharmacological characterization of cholest-4-en-3-one
Lee J Martin et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(1), 359-370 (2011-01-07)
Ablation of mouse occipital cortex induces precisely timed and uniform p53-modulated and Bax-dependent apoptosis of thalamocortical projection neurons in the dorsal lateral geniculate nucleus (LGN) by 7 d after lesion. We tested the hypothesis that this neuronal apoptosis is initiated
Lyudmila I Rachek et al.
Toxicology and applied pharmacology, 240(3), 348-354 (2009-07-28)
Thiazolidinediones (TZDs), such as troglitazone (TRO) and rosiglitazone (ROSI), improve insulin resistance by acting as ligands for the nuclear receptor peroxisome proliferator-activated receptor-gamma (PPARgamma). TRO was withdrawn from the market because of reports of serious hepatotoxicity. A growing body of
-
What is the Department of Transportation shipping information for this product?
1 answer-
Helpful?
-
-
What is the structure of TRO 19622, Product T3077?
1 answer-
Please see the following reference for more information: T. Bordet et al., Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis. J. Pharmacol. Exp. Ther., 322, 709-720 (2007).
Helpful?
-
-
What is the solubility of TRO 19622, Product T3077?
1 answer-
This compound is soluble in DMSO (> 10mg/ml).
Helpful?
-
-
How does TRO 19622, Product T3077 work?
1 answer-
TRO 19622 interacts with the mitochondrial permeability transition pore (mPTP). By interacting with protein components of the mPTP, it prevents the release of apoptotic factors and therefore protects the neuron. This mechanism of action may lead to a general neuroprotective activity. Please see the following reference for more information: T. Bordet et al., Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis J. Pharmacol. Exp. Ther. 322, 709-720, (2007)
Helpful?
-
Active Filters
Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.
Póngase en contacto con el Servicio técnico