Analytical Standards

Reference Materials & Analytical Standards from RTC

Sigma-Aldrich RTC products include high quality Certified Reference Materials (CRMs), Quality Control (QC) Samples, and Proficiency Testing (PT) Samples. RTC has more than 20 years of experience and strong expertise in the environmental and pharmaceutical sectors. RTC was also one of the original Proficiency Test providers recognized by the US EPA. Quality systems are based upon the accreditation to ISO/IEC 17025:2005, ISO Guide 34:2009, ISO/IEC 17043:2010 and registration to ISO 9001:2008. In addition, Sigma-Aldrich RTC is an accredited TNI Proficiency Testing provider. Please refer to the applicable scope of accreditation for specific details.

RTC Product Availability via Sigma-Aldrich
The management at RTC assures our customers that the level of service, product quality, and product offerings you have come to expect will not diminish as a result of our merger with Sigma-Aldrich - only our name changes to Sigma-Aldrich RTC; not our people and our service. We hope to leverage the global presence and distribution capabilities of Sigma-Aldrich to enhance our reach and quality of service, thereby solidifying our position as an industry leader in analytical standards and reference materials.

Product Portfolio


About RTC

Traceable Secondary Pharmaceutical Reference Standards

RTC Pharmaceutical Reference Standards (PRS) are certified reference materials (CRMs) manufactured and certified in accordance to ISO Guide 34:2009 and ISO/IEC 17025:2005. These standards are secondary reference materials that are qualified to and traceable to the major pharmacopoeia standards. RT Pharma PRS products represent the first commercially available harmonized pharmaceutical standards available. Every PRS product is supplied with a Certificate of Analysis (COA), which is among the most extensive in the industry. PRS products are not only economical but enhance quality by providing larger quantities of material for measurement.

Find a comprehensive overview on our Pharmaceutical Secondary Standards.
View Secondary Pharma Reference Standards Product List

Reference Materials for Microbiological Testing

Is your micro laboratory still spending time preparing stock and working cultures in-house? Ready-to-use microbiological reference materials  - available at convenient CFU levels - enable quicker, more reproducible QC testing for your laboratory.  Vitroids™ are microbiological certified reference materials (CRMs) which are manufactured and certified in accordance to ISO Guide 34:2009 and ISO/IEC 17025:2005,

The proprietary and patented Vitroids technology for stabilizing microorganisms minimizes stress during the storing process. This technology offers significant advantages over other stabilization technologies.

Unlike many other microbiological standards, Vitroids offer:
1) Enhanced long term stability
2) High organism viability
3) No Recovery or pre-incubation time

This means Vitroids are easier and faster to use, saving busy laboratory analysts time. In addition, they offer users enhanced flexibility, and are easily adaptable to any laboratory SOP in a wide variety of applications, including:

  • Environmental
  • Pharmaceutical
  • Food and Water

Vitroids (VT) microbiological standards are derived from, and directly traceable to, the CECT® Spanish Type Culture Collection.

View Microbiology Quality Control Standards Product List
View Vitroids CRMs Product List

We are also proud to offer the microbiology community access to LENTICULE® discs, manufactured under license from Public Health England.

View LENTICULE Disc Certified Reference Materials


Environmental Matrix Reference Materials

A certified reference material is defined as a reference material, characterized by a metrologically valid procedure for one or more specified property, its associated uncertainty and a statement of metrological traceability.

RTC is accredited to certify CRMs and has become the world leader in the production and certification of soil and sediment Certified Reference Materials. All CRMs are either natural matrix materials or natural matrices in which selected analytes have been fortified to give the resultant CRM an analyte profile that meets the needs of the market.

In certification of the RTC CRMs, data developed from multi-laboratory analysis is supported by in-house data, and a robust statistical program is used. Most CRMs are method specific; the certificate shows a confidence interval, uncertainty, prediction value, and expanded uncertainty, in addition to the mean value and standard deviation from the mean.

Certified Reference Material development started at RTC more than 20 years ago. RTC has collected soils and solid wastes from contaminated sites around the United States to produce real-world CRMs for the USEPA. Since then, the product range has grown and now includes a wide range of natural-matrix CRMs. RTC Environmental Matrix Reference Materials are certified reference materials (CRMs) manufactured and certified in accordance to ISO Guide 34:2009 and ISO/IEC 17025:2005.

View Environmental Matrix CRM Product List

About RTC

RT Corp was incorporated in Laramie, Wyoming in 1988. The principal business of the corporation is the manufacture and distribution of Certified Reference Materials (CRMs), Quality Control (QC) Samples, and Proficiency Testing (PT) Samples. Originally focused in the environmental sector, RT Corp has since expanded its focus to include the pharmaceutical sector. Since its inception, RT Corp has become world famous for its production of "Real World" CRMs and fortified matrices CRMs. RT Corp was one of the original Proficiency Test providers recognized by the US EPA.

RTC is located in Laramie, Wyoming on the edge of town at the confluence of Interstate 80 and Highway 287, a major North/South and East/West artery. Laramie is a community of 25,000 located in the Southeast corner of the state, 130 miles North of Denver, 60 miles North of Fort Collins and 45 miles West of Cheyenne. Laramie is also the home of the University of Wyoming, which provides a readily available and highly educated labor base.

Since RT Corp's inception, the company has strategically expanded to maximize efficiency while minimizing overhead. In 2004 RT Corp expanded into its new facility. The RTC Campus is situated on 4 ½ acres spread between 3 buildings. The new building provides an additional 21,600 sq ft of space. RT Corp expects to bring on-line additional laboratory and manufacturing space to meet increasing demand.

Permits and Accreditations

ANAB accredited ISO/IEC 17043:2010 Proficiency Testing Provider (cert #:  AP-1469)
ANAB accredited ISO/IEC 17025:2005 Testing Laboratory (cert #:  AT-1467)
ANAB accredited ISO/IEC Guide 34:2009 Reference Material Producer (cert #:  AR-1470)
DQS accredited ISO 9001:2015 Quality Management System (cert #:  005356 QM 15 Location 527765)
EPA ID # WYD9888870218

Click to view RTC (Laramie site) Accreditation Details