EMAIL THIS PAGE TO A FRIEND

Bioorganic & medicinal chemistry

New oxirane derivatives of 1,4-naphthoquinones and their evaluation against T. cruzi epimastigote forms.


PMID 22795899

Abstract

New oxirane derivatives were synthesized using six naphthoquinones as the starting materials. Our biological results showed that these oxiranes acted as trypanocidal agents against Trypanosoma cruzi with minimal cytotoxicity in the VERO cell line compared to naphthoquinones. In particular, oxirane derivative 14 showed low cytotoxicity in a mammalian cell line and exhibited better activity against epimastigote forms of T.cruzi than the current drug used to treat Chagas disease, benznidazole.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

70372
1,4-Naphthoquinone, purum, ≥96.5% (HPLC)
C10H6O2
152757
1,4-Naphthoquinone, 97%
C10H6O2