Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society

Quantifying the effects of inactin vs Isoflurane anesthesia on gastrointestinal motility in rats using dynamic magnetic resonance imaging and spatio-temporal maps.

PMID 25257924


Anesthetics are commonly applied in animal studies of gastrointestinal (GI) function. Different anesthetics alter smooth-muscle motility in different ways. The aim of this study is to quantify and compare non-invasively with magnetic resonance imaging (MRI) the motility patterns of the rat gut when anesthetized with inactin vs isoflurane anesthetics in the fed state. Rats were given an oral gavage of MRI contrast agent for improved visualization of the GI tract. Two-dimensional images through the jejunum of the pre- and postanesthetized rat in the fed state were acquired every 168xa0ms. Image registration, segmentation, and postprocessing algorithms were applied to produce spatio-temporal maps that were used to quantify peristaltic and segmental motions in the jejunum region interspersed between periods of inactivity. There were significantly longer periods of inactivity in the rats treated with isoflurane than in those treated with inactin (179.9xa0±xa022.4xa0s vs 17.7xa0±xa010.3xa0s). The speed of propagation and wavelength of peristalsis, and the frequency and speed of pattern switching of segmental motility, were higher (pxa0

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Inactin® hydrate, ≥98% (HPLC)
C10H15N2NaO2S · xH2O