KCNQ4
potassium voltage-gated channel, KQT-like subfamily, member 4
Sinónimos:
DFNA2, DFNA2A, KV7.4
Especie:
Human KCNQ4 (9132), Mouse Kcnq4 (60613), Rat Kcnq4 (298496), chicken KCNQ4 (419643), naked mole-rat Kcnq4 (101714294), domestic guinea pig Kcnq4 (100716024), sheep KCNQ4 (101122655), Domestic Rabbit KCNQ4 (100358271), domestic cat KCNQ4 (101091641), Horse KCNQ4 (100067963) ...Más
ID UniProtKB:
ID del gen:
- Human(9132) Summary: The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2 (DFNA2), an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Mouse(60613) potassium voltage-gated channel, subfamily Q, member 4
- Rat(298496) potassium voltage-gated channel, KQT-like subfamily, member 4
- chicken(419643) potassium voltage-gated channel, KQT-like subfamily, member 4
- naked mole-rat(101714294) potassium voltage-gated channel, KQT-like subfamily, member 4
- domestic guinea pig(100716024) potassium voltage-gated channel, KQT-like subfamily, member 4
- sheep(101122655) potassium voltage-gated channel, KQT-like subfamily, member 4
- Domestic Rabbit(100358271) potassium voltage-gated channel, KQT-like subfamily, member 4
- domestic cat(101091641) potassium voltage-gated channel, KQT-like subfamily, member 4
- Horse(100067963) potassium voltage-gated channel, KQT-like subfamily, member 4
- cow(528741) potassium voltage-gated channel, KQT-like subfamily, member 4
- dog(482451) potassium voltage-gated channel, KQT-like subfamily, member 4
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