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L-Thyroxine

Name: <SC>L</SC>-Thyroxine
Brand: SIGMA
Price: 30.3 USD
Availability: InStock

synthetic, ≥98% (HPLC), Metabolism activator, powder

Synonym(s):

3,3′,5,5″-Tetraiodo-L-thyronine, 3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-L-alanine, T₄

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Size/SKU	Availability	Price
100 mg	Check Cart for Availability	$30.30
500 mg	Available to ship TODAYfromMILWAUKEE	$81.90
1 g	Available to ship TODAY	$129.00
5 g	Check Cart for Availability	$489.00

About This Item

Linear Formula:

HOC₆H₂(I)₂OC₆H₂(I)₂CH₂CH(NH₂)CO₂H

CAS Number:

51-48-9

Molecular Weight:

776.87

NACRES:

NA.32

PubChem Substance ID:

24900033

UNSPSC Code:

51111800

EC Number:

200-101-1

MDL number:

MFCD00002595

Beilstein/REAXYS Number:

2228515

eCl@ss:

32190102

Biological source:

synthetic

Form:

powder

Assay:

≥98% (HPLC)

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Properties

Product Name

L-Thyroxine, ≥98% (HPLC)

biological source

synthetic

Quality Segment

200

sterility

non-sterile

assay

≥98% (HPLC)

form

powder

technique(s)

cell culture | mammalian: suitable

mp

223 °C (dec.) (lit.)

solubility

4 M NH₄OH in methanol: 50 mg/mL, clear to hazy, yellow

shipped in

ambient

storage temp.

room temp

SMILES string

N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O

InChI

1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1

InChI key

XUIIKFGFIJCVMT-LBPRGKRZSA-N

Gene Information

human ... THRA(7067), THRB(7068), TTR(7276)
mouse ... Cnr2(12802)
rat ... Cnr1(25248)

Description

Application

L-Thyroxine was used to study the light-induced hormone conversion of T4 to T3 in regulation of photoperiodic response of gonads in Japanese quail. The product was used as a test compound for studying the impact of numerous hormones on the surface morphology of rat testicular cells in culture.

Biochem/physiol Actions

L-Thyroxine is an iodine containing hormone produced from thyroglobulin in the thyroid follicular cells. L-Thyroxine reduces total cholesterol level, low-density lipoprotein cholesterol as well as waist to hip ratio in subclinical hypothyroidism pateints. Hence, facilitates in improving cardiovascular risk factor as well as can enhance symptoms of tiredness.

L-Thyroxine (T₄) and triiodo-L-thyronine (T₃) are iodine-containing hormones produced from thyroglobulin in the thyroid follicular cells. The stimulation of metabolic rate and regulation of growth and development by these hormones appear to be due to their effects on DNA transcription and, thus, protein synthesis.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Preparation Note

L-Thyroxine dissolves in 4M ammonium hydroxide in Methanol at 50 mg/ml to yield a clear to hazy yellow to dark yellow solution.

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1 of 1

This Item	T1775	T2877	T5516
Sigma-Aldrich T2376 L-Thyroxine	Sigma-Aldrich T1775 L-Thyroxine	Sigma-Aldrich T2877 3,3′,5-Triiodo-L-thyronine	Sigma-Aldrich T5516 3,3′,5-Triiodo-L-thyronine sodium salt
description ≥98% (HPLC)	description powder, BioReagent, suitable for cell culture	description ≥95% (HPLC), powder	description γ-irradiated, powder, suitable for, suitable for cell culture
biological source synthetic	biological source synthetic	biological source synthetic (organic)	biological source synthetic (organic)
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥95% (HPLC)	assay ≥90% (HPLC)
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200
technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) transfection: suitable	technique(s) cell culture \| mammalian: suitable
form powder	form powder	form powder	form powder
storage temp. room temp	storage temp. room temp	storage temp. −20°C	storage temp. −20°C

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Pictograms

GHS08

Signal Word

Danger

Hazard Codes

H372

Precautionary Statements

P260 - P264 - P270 - P314 - P501

Hazard Classifications

STOT RE 1

Target Organs

Thyroid,Cardio-vascular system,Kidney

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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