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A2856

Anti-ATG7 antibody produced in rabbit

Name: Anti-ATG7 antibody produced in rabbit
Brand: SIGMA
Price: 157 EUR

affinity isolated antibody, buffered aqueous solution

Synonyme(s) :

Anti-APG7, Anti-APG7-like, Anti-APG7L, Anti-Apoptosis-specific-protein, Anti-Autophagy protein 7-like, Anti-Ubiquitin activating enzyme E1-like protein

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À vous/Référence	Disponibilité	Prix
25 μL	Vérifier la disponibilité des articles du panier	157,00 €
200 μL	Vérifier la disponibilité des articles du panier	558,00 €

A propos de cet article

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD09753848

Conjugate:

unconjugated

Clone:

polyclonal

Application:

IP, WB

Citations:

155

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Propriétés

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~75 kDa

species reactivity

rat, human, mouse

packaging

antibody small pack of 25 μL

technique(s)

immunoprecipitation (IP): 1-2 μL using human U87 cell lysate, western blot: 0.5-1 μg/mL using whole extracts of mouse 3T3 cells

UniProt accession no.

O95352

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ATG7(10533)
mouse ... Atg7(74244)
rat ... Atg7(312647)

Description

General description

Autophagy is a catabolic process by which cell delivers cytoplasmic constituent into lysosome for protein degradation. 16 ATG genes are essential for autophagosome preparation out of which Atg7 is the one required to activate ubiquitin-like proteins Atg12 and Atg8. Atg7 is also crucial for amino acid supply in neonates, as well as for bulk degradation of proteins and organelles in mice during starvation. Anti-ATG7 antibody can be used in immunohistochemistry and immunoprecipitation. Rabbit anti-ATG7 antibody reacts specifically with Atg7 of human, mouse and rat.

Immunogen

synthetic peptide corresponding to amino acids 38-50 of human ATG7, conjugated to KLH via a C-terminal cysteine residue. The corresponding sequence is identical in mouse and rat.

Application

Anti-ATG7 antibody can be used in western blotting and immunoblotting.

Anti-ATG7 antibody produced in rabbit has been used:

for quantitative real-time polymerase chain reaction of autophagy-related genes
in immunofluorescence and immunoblotting
in in vivo acetylation/deacetylation of autophagy proteins

Rabbit anti-ATG7 antibody has been used for immunoblotting assays. The antibody is also suitable for use in immunoprecipitation applications at 1-2μL using human U87 cell lysates.

Rabbit anti-ATG7 antibody was used for immunohistochemistry on sections of mouse midbrain fixed in 4% paraformaldehyde at 1:2000.

Biochem/physiol Actions

Autophagy related 7 (ATG7) regulates caspase mediated autophagy and apoptosis. This has a significant effect on tumor progression and ATG7 acts as a tumor suppressor. ATG7 is known to be associated with many cancer types, hence it is considered as a target for cancer therapy. Loss of ATG7 gene contributes to liver carcinogenesis. The ATG7 gene encodes E1-like enzyme essential for lipidation and conjugation systems : ubiquitin-like microtubule-associated protein 1A/1B-light chain 3 (LC3) and autophagy related 12 (ATG12) respectively.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Cet article	HPA007639	SAB5700649	SAB5701289
Sigma-Aldrich A2856 Anti-ATG7 antibody produced in rabbit	Sigma-Aldrich HPA007639 Anti-ATG7 antibody produced in rabbit	Sigma-Aldrich SAB5700649 Anti-ATG7 antibody produced in rabbit	Sigma-Aldrich SAB5701289 Anti-ATG3 antibody produced in rabbit
description affinity isolated antibody, buffered aqueous solution	description Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution	description -	description -
Quality Level 200	Quality Level 100	Quality Level 100	Quality Level 100
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form -
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
species reactivity rat, human, mouse	species reactivity human	species reactivity rat, mouse, human	species reactivity human, mouse, rat
form buffered aqueous solution	form buffered aqueous glycerol solution	form buffered aqueous solution	form liquid

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