Liquid Solutions

Liquid Manufacture Capability & Capacity

SAFC continues to progress its cGMP liquid manufacturing facilities and capabilities to meet or exceed current industry requirements. SAFC routinely provides a wide range of bulk liquid lot sizes ranging 50L – 10,000L suitable for use in clinical and commercial manufacturing processes.

  • Cell Culture Media
  • Upstream Buffers and Additives
  • Downstream Purification Buffers
  • Cleaning Solutions
  • Bulk Water (WFI – grade source)

HTST Capabilities - Glucose

HTST pasteurization is a highly effective method to inactivate viruses. It involves the rapid heating of the material to a predetermined temperature (>100 °C) and holding it at that temperature for a specified time to inactivate adventitious viral agents that may be present. This technology has been typically used as an in-house treatment for high risk bioreactor feeds, such as glucose, and is becoming an integral part of many biopharmaceutical companies’ viral risk-mitigation strategies.

To learn more, download our data sheet.

To learn more about viral safety, please visit here


Filtered Buffer Concentrates

BioContinuum™ Buffer Delivery Platform

Intensified upstream production has a direct impact on the demand for buffer production downstream, which is often a dedicated, and significant portion of the facility footprint, labor and equipment cost. As downstream operations are essentially product-mass-based, an increase in productivity upstream will lead to a proportional increase in demand for buffers downstream.

Buffer concentrates provide you with a method to meet the increasing demands on today’s buffer preparation and delivery while reducing your facility footprint and CAPEX. This approach allows you to streamline your process, eliminate the contamination risks often associated with powder hydration, and allows you to reallocate your labor typically associated with buffer preparation. This concentrated buffer method is easily implemented in both new and existing facilities.

Our ready-to-use buffer concentrates are pre-titrated, so limited adjustment after dilution is required.

  • 26 common buffers have been identified and assessed for maximum concentration and stability
  • Concentration factors > 50x can be achieved for some buffers, significantly reducing operating footprint
  • The highest quality raw materials are used in the manufacture of our concentrates
  • Our clean, robust packaging has undergone ISTA testing to ensure the safe delivery of the buffer to your process

Our BioContinuum™ Buffer Delivery Platform combines our buffer concentrates, buffer dilution system, and Mobius® single-use assemblies to provide accurate and precise delivery of ready-to-use buffer concentrates while alleviating process bottlenecks and reducing your facility footprint.

To learn more, download our data sheet.

To learn more about our BioContinuum™ Buffer Delivery Platform, visit here.

2D Bag Transport Solution – Hammock Packaging

Our new hammock packaging has been designed to protect highly valuable liquid and frozen products during the transport.

The hammock packaging is a smart solution to keep the product firmly in place during transport while also reducing the overall environmental impact of packaging material by using fully recyclable materials.

Dual Liquid Manufacturing Sites

Dual liquid production sites strategically located in North America (Broadway) and Europe (Irvine) have the capacity to support customers with on-going large volume liquid requirements. Both facilities are supported by a single Global Quality System and operated with an aligned local Quality Program.

Bulk Liquid Packaging

SAFC has selected the industry’s leading biopharmaceutical-grade polyethylene-based film, TepoFlex® provided by Meissner as the premier solution for our bulk liquid packaging systems. Innovative in composition, TepoFlex® breaks with the legacy of prevailing films and is one of the most fit-for-purpose films available for biopharmaceutical applications. Manufactured and extruded in ISO Class 7 cleanrooms, the TepoFlex® film is characterized by a comprehensive Leachable and Extractable assessment available for review under confidentiality.

SAFC Bulk Liquid Handling Capabilities

Technical Support
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