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Merck

251680

Dantrolene sodium salt

≥95% (HPLC), Ryanodine receptor blocker, solid

Synonym(e):

Dantrolene, Sodium Salt

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Über diesen Artikel

Empirische Formel (Hill-System):
C14H9N4O5 · Na
CAS-Nummer:
14663-23-1
Molekulargewicht:
336.23
MDL-Nummer:
MFCD00079130
UNSPSC-Code:
12352200
NACRES:
NA.77

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Produktname

Dantrolene, Sodium Salt, A cell-permeable blocker of intracellular calcium release from the sarcoplasmic reticulum that acts by binding to the ryanodine receptor.

Qualitätsniveau

100

Beschreibung

Merck USA index - 14, 2816

Assay

≥95% (HPLC)

Form

solid

Hersteller/Markenname

Calbiochem®

Lagerbedingungen

OK to freeze
desiccated (hygroscopic)

Farbe

orange

Löslichkeit

DMSO: 3 mg/mL
aqueous base: soluble

Versandbedingung

ambient

Lagertemp.

10-30°C

SMILES String

[Na]N1C(=O)N(CC1=O)\N=C\c2[o]c(cc2)c3ccc(cc3)[N+](=O)[O-]

InChI

1S/C14H10N4O5.Na/c19-13-8-17(14(20)16-13)15-7-11-5-6-12(23-11)9-1-3-10(4-2-9)18(21)22;/h1-7H,8H2,(H,16,19,20);/q;+1/p-1/b15-7+;

InChIKey

KSRLIXGNPXAZHD-HAZZGOGXSA-M

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Dieser Artikel
126855474705D9175
Dantrolene, Sodium Salt A cell-permeable blocker of intracellular calcium release from the sarcoplasmic reticulum that acts by binding to the ryanodine receptor.

Sigma-Aldrich

251680

Dantrolene, Sodium Salt

Alendronate, Sodium Salt An amino-bisphosphonate that acts as a potent inhibitor of bone resorption and cartilage destruction.

Sigma-Aldrich

126855

Alendronate, Sodium Salt

Mevastatin, Natriumsalz Carboxylate form of Mevastatin that is active in whole cells and in cell-free assays.

Sigma-Aldrich

474705

Mevastatin, Natriumsalz

Dantrolene sodium salt

Sigma-Aldrich

D9175

Dantrolene sodium salt

assay

≥95% (HPLC)

assay

≥98% (titration)

assay

≥98% (TLC)

assay

-

form

solid

form

solid

form

solid

form

solid

Quality Level

100

Quality Level

100

Quality Level

200

Quality Level

200

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

-

storage temp.

10-30°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

-

storage condition

OK to freeze, desiccated (hygroscopic)

storage condition

OK to freeze, desiccated (hygroscopic)

storage condition

OK to freeze, desiccated (hygroscopic)

storage condition

-

Allgemeine Beschreibung

A cell-permeable blocker of intracellular calcium release from the sarcoplasmic reticulum that acts by binding to the ryanodine receptor. Inhibits long-term depression and depotentiation of synaptic transmission. Has neuroprotective effects in cases of cerebral ischemia.
A skeletal muscle relaxant. Blocks intracellular calcium release from the sarcoplasmic reticulum during excitation-contraction coupling by binding to the ryanodine receptor. Blocks long-term depression and depotentiation.

Biochem./physiol. Wirkung

Cell permeable: yes
Primary Target
Ryanodine receptor
Product does not compete with ATP.
Reversible: no

Angaben zur Herstellung

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Sonstige Hinweise

Wei, H., and Perry, D.C. 1996. J. Neurochem. 67, 2390.
O’Mara, S.M., et al. 1995. Neuroscience68, 621.
Parness, J., and Palnitkar, S.S. 1995. J. Biol. Chem.270, 18465.
Zhang, H., et al. 1995. Am. J. Physiol. 269, H1874.
Hotchkiss, R.S., and Karl, I.E. 1994. Proc. Natl. Acad. Sci. USA91, 3039.
Song, S.K., et al. 1994. Proc. Natl. Acad. Sci. USA91, 3039.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Haftungsausschluss

Toxicity: Harmful (C)

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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