Solutions prepared in DMSO at 50 mg/mL may be stored in working aliquots at -20°C for up to 1 year. Avoid repeated freeze/thaw cycles.
Fortfahren mit
92131
Trimethoprim
≥99.0% (HPLC)
Aktionsangebot verfügbar
Synonym(e):
2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidin, NSC 106568
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| Größe/SKU | Verfügbarkeit | Preis |
|---|---|---|
1 g | Warenkorb auf Verfügbarkeit prüfen | € 50,00 |
5 g | Warenkorb auf Verfügbarkeit prüfen | € 186,00 |
25 g | Warenkorb auf Verfügbarkeit prüfen | € 714,00 |
Über diesen Artikel
Empirische Formel (Hill-System):
C14H18N4O3
CAS-Nummer:
Molekulargewicht:
290.32
UNSPSC Code:
51285203
NACRES:
NA.85
PubChem Substance ID:
EC Number:
212-006-2
Beilstein/REAXYS Number:
625127
MDL number:
Technischer Dienst
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Unterstützung erhaltenbiological source
synthetic
Quality Segment
assay
≥99.0% (HPLC)
form
powder
color
white to light yellow
mp
≥199.0 °C
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria, mycobacteria
mode of action
DNA synthesis | interferes, enzyme | inhibits
storage temp.
2-8°C
SMILES string
COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC
InChI
1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18)
InChI key
IEDVJHCEMCRBQM-UHFFFAOYSA-N
Gene Information
human ... DHFRP1(573971), KCNH1(3756)
rat ... Dhfr(24312)
General description
Chemical structure: pyrimidine
Application
Trimethoprim is primarily used as an antibacterial agent. It is used in susceptibility studies of Mycobacterium tuberculosis and mechanism of resistance studies in Haemophilus influenzae .
Antibakterieller Wirkstoff, Dihydrofolatreduktase-Inhibitor mit Selektivität für prokaryotische Enzyme.
Biochem/physiol Actions
Inhibits the synthesis of tetrahydrofolate by procaryote specific dihydrofolate reductase (DHFR).
Trimethoprim is a dihydrofolate reductase inhibitor with selectivity for the prokaryote enzyme.
Packaging
1g,5g,25g
Other Notes
Keep container tightly closed in a dry and well-ventilated place.Light sensitive. Store under inert gas. Moisture sensitive. Product is sensitive to light and moisture.
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Dieser Artikel | |||
|---|---|---|---|
| description ≥99.0% (HPLC) | description ≥98.5% | description VETRANAL®, analytical standard | description certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland |
| mode of action enzyme | inhibits, DNA synthesis | interferes | mode of action DNA synthesis | interferes, enzyme | inhibits | mode of action DNA synthesis | interferes, enzyme | inhibits | mode of action - |
| antibiotic activity spectrum Gram-positive bacteria, Gram-negative bacteria, mycobacteria | antibiotic activity spectrum mycobacteria, Gram-negative bacteria, Gram-positive bacteria | antibiotic activity spectrum mycoplasma, Gram-negative bacteria, Gram-positive bacteria | antibiotic activity spectrum - |
| Quality Level 200 | Quality Level 200 | Quality Level 100 | Quality Level 300 |
| form powder | form powder | form - | form - |
| assay ≥99.0% (HPLC) | assay ≥98.5% | assay - | assay - |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
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Signalwort
Warning
Gefahrencodes
Sicherheitshinweise
Hazard Classifications
Acute Tox. 4 Oral - Repr. 2
Lagerklasse
11 - Combustible Solids
Was ist los?
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
PSA (Persönliche Schutzausrüstung)
Eyeshields, Gloves, type N95 (US)
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Upon dilution in DMSO, what is the best storage condition for trimethoprim (fridge/freezer, how long is it stable for)?
1 answer-
Helpful?
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Is Trimethoprim soluble in DMSO or water?
1 answer-
The solubility of this product is not analyzed on a lot-to-lot basis. The compound is expected to be soluble in water at 0.4 mg/ml, ethanol at 2.6 mg/ml, methanol at 12.1 mg/ml, chloroform at 22.2 mg/ml, and DMSO at 50 mg/ml.
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
Helpful?
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Is Trimethoprim stable in solution?
1 answer-
Triemethoprim in a solution of 52% N,N dimethylacetamide:48% propylene glycol at 50 mg/ml is stable when stored at 25° C. There is only a 10% degradation of trimethoprim under these conditions after 885 days.
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