C104

(±)-CPP

solid

• Synonym(e): (±)-3-(2-Carboxypiperazin-4-yl)propyl-1-phosphonic acid
• Empirische Formel (Hill-System): C₈H₁₇N₂O₅P
• CAS-Nummer: 100828-16-8
• Molekulargewicht: 252.20
• NACRES: NA.77
• PubChem Substance ID: 24277958
• UNSPSC Code: 12352200
• MDL number: MFCD00055136

Eigenschaften

• form: solid
• Quality Segment: 100
• color: white
• solubility: H₂O: 99.2 mg/mL, ethanol: insoluble
• SMILES string: OC(=O)C1CN(CCCP(O)(O)=O)CCN1
• InChI: 1S/C8H17N2O5P/c11-8(12)7-6-10(4-2-9-7)3-1-5-16(13,14)15/h7,9H,1-6H2,(H,11,12)(H2,13,14,15)
• InChI key: CUVGUPIVTLGRGI-UHFFFAOYSA-N
• Gene Information: human ... GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRINA(2907) ; rat ... Grin2a(24409)

Beschreibung

Application

(±)-CPP has been used as an uncompetitive NMDA receptor antagonist:

• to study its effects on blood glucose in mice
• in electrophysiological recording in mouse brain slices
• in electrophysiological recording in rat hippocampal pyramidal neurons

Biochem/physiol Actions

3-(2-carboxypiperazin-4yl) propyl-1-phosphonic acid (CPP) is a potent, competitive, and selective N-methyl-D-aspartate (NMDA) receptor antagonist. It is an analog of 2-amino-7-phosphonoheptanoic acid. CPP shows anticonvulusant and antinociceptive activity.

Disclaimer

Hygroscopic

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• Gefahrencodes: H315,H319,H335
• Sicherheitshinweise: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• PSA (Persönliche Schutzausrüstung): dust mask type N95 (US), Eyeshields, Gloves