This understanding is correct, however, the stabilizer content is approximately 70%. The lot-specific Certificate of Analysis will provide the exact stabilizer content, which can then be used to calculate the amount of β-Estradiol 3-Sulfate.
https://www.sigmaaldrich.com/product/sigma/e9505#product-documentation
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E9505
β-Estradiol 3-sulfate sodium salt
≥93%
Synonym(e):
1,3,5(10)-Estratriene-3,17β-diol 3-sulfate, 3,17β-Dihydroxy-1,3,5(10)-estratriene 3-sulfate
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Über diesen Artikel
Lineare Formel:
C18H23O5SNa
CAS-Nummer:
Molekulargewicht:
374.43
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
Assay:
≥93%
Form:
powder
sterility
non-sterile
Quality Segment
assay
≥93%
form
powder
contains
~70% N-methyl-
solubility
methanol: 9.80-10.20 mg/mL, clear, colorless to faintly yellow
shipped in
ambient
storage temp.
room temp
SMILES string
[Na].[H][C@]12CC[C@]3(C)[C@@H](O)CC[C@@]3([H])[C@]1([H])CCc4cc(OS(O)(=O)=O)ccc24
InChI
1S/C18H24O5S.Na.H/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19;;/h3,5,10,14-17,19H,2,4,6-9H2,1H3,(H,20,21,22);;/t14-,15-,16+,17+,18+;;/m1../s1
InChI key
PYPVMTJYMKHIST-LBARCDFESA-N
General description
β-Estradiol is secreted by developing ovaries and is predominant during premenopause in women.
Application
β-Estradiol 3-sulfate sodium salt has been used to measure the estradiol level from culture supernatant in ultra-performance liquid chromatography-tandem mass spectrometry.
Biochem/physiol Actions
β-Estradiol is a steroid hormone involved in a number of organ functions. It is significantly associated with brain functions including neuroprotection, neurogenesis and synaptic plasticity. β-Estradiol maintains bone homeostasis, hence it is preferred for osteoporosis therapy. 17-β-Estradiol is the most active estrogen generated in our body. During postmenopausal, 17-β-estradiol inhibits oxidative modification in low density lipoprotein. This indicates that estrogen replacement therapy might be useful in treating cardiovascular disease.
Packaging
Package size based on steroid content
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2
Lagerklasse
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
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The description of the product says that it contains 70 % N-methyl-D-glucamine as a stabilizer. Does this mean that 1.0 mg of the powder contains 0.3 mg of β-Estradiol 3-sulfate and that I need to weigh in 3.33 mg of the powder to get 1 mg of substance?
1 answer-
Helpful?
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