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M0252

Methylglyoxal -Lösung

~40% in H2O

Synonym(e):

Acetylformaldehyd, Pyruvaldehyd

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Über diesen Artikel

Lineare Formel:
CH3COCHO
CAS-Nummer:
78-98-8
Molekulargewicht:
72.06
UNSPSC Code:
12352204
NACRES:
NA.32
PubChem Substance ID:
24896540
MDL number:
MFCD00006960
Beilstein/REAXYS Number:
906750
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Technischer Dienst
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Unterstützung erhalten

form

liquid

Quality Segment

concentration

~40% (enzymatic), ~40% in H2O

density

1.17 g/mL at 25 °C (lit.)

storage temp.

2-8°C

SMILES string

[H]C(=O)C(C)=O

InChI

1S/C3H4O2/c1-3(5)2-4/h2H,1H3

InChI key

AIJULSRZWUXGPQ-UHFFFAOYSA-N

General description

Methylglyoxal (MG) ist ein Glucosemetabolit, der bei Diabetikern mit peripherer Neuropathie und Schmerzen in Verbindung steht. Es verstärkt das intrazelluläre Calcium in sensorischen Neuronen und erzeugt die verhaltensbezogene Nozizeption. Methylglyoxal weist antibakterielle Eigenschaften auf. MG dient als Proteinglykationsmittel und Vorläufer von fortgeschrittenen Glykationsendprodukten. Es beeinträchtigt die diabetische Wundheilung.

Application

Methylglyoxallösung wird wie folgt verwendet:
  • zur Bewertung der Glyoxalase 1-Enzymaktivität (GLO1)
  • als Advanced Glycation End-Bildungsmittel (AGE) zur Herstellung von Albumin in vitro
  • zur Regulierung von angstähnlichem Verhalten bei Mäusen
  • zur Einleitung von peritonealer Fibrose bei Ratten
  • zur Untersuchung der chromatografischen Retentionseigenschaften von organischen Chemikalien und Metall-DNA-Addukten
  • zur intraplanaren Injektion bei Mäusen zur Untersuchung der peripheren und zentralen Komponenten des Methylglyoxal(MG)-Transient receptor potential Ankyrin 1 (TRPA1)-Adenylycyclase 1 Isoform (AC1)-Wegs

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Dieser Artikel
W29690267028SAB5202580
Methylglyoxal -Lösung ~40% in H2O

Sigma-Aldrich

M0252

Methylglyoxal -Lösung

Methylglyoxal -Lösung 40 wt. % in H2O

Sigma-Aldrich

W296902

Methylglyoxal -Lösung

Methylglyoxal -Lösung technical, ~40% in H2O

Sigma-Aldrich

67028

Methylglyoxal -Lösung

Monoclonal Anti-Methylglyoxal antibody produced in mouse clone 9F11

Sigma-Aldrich

SAB5202580

Monoclonal Anti-Methylglyoxal antibody produced in mouse

description

~40% in H2O

description

40 wt. % in H2O

description

technical, ~40% in H2O

description

clone 9F11

Quality Level

200

Quality Level

400, 300

Quality Level

200

Quality Level

-

form

liquid

form

-

form

-

form

buffered aqueous solution

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

density

1.17 g/mL at 25 °C (lit.)

density

1.178 g/mL at 25 °C

density

1.19 g/mL at 20 °C

density

-

concentration

~40% in H2O

concentration

40 wt. % in H2O

concentration

~40% in H2O

concentration

1.0 mg/mL

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Signalwort

Danger

Gefahrencodes

H290,H317,H318,H341

Hazard Classifications

Eye Dam. 1 - Met. Corr. 1 - Muta. 2 - Skin Sens. 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

PSA (Persönliche Schutzausrüstung)

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Lagerklasse

10 - Combustible liquids

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Analysenzertifikate (COA)

Lot/Batch Number

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Questions

1–8 of 8 Questions  

  1. What Solvent should I use first to make intermediate stock eg 5mL of 10mM from 6.49M? final working solution i will use for Cell cytotoxicity test.

    1 answer

    1. Researchers indicate this product has been diluted in PBS for cytotoxicity assays. Please refer to the citation below and consider reviewing peer reviewed literature for application specific information.

      He, T., Zhou, H., Li, C., Chen, Y., Chen, X., Li, C., … Meng, Q. H. (2016). Methylglyoxal suppresses human colon cancer cell lines and tumor growth in a mouse model by impairing glycolytic metabolism of cancer cells associated with down-regulation of c-Myc expression. Cancer Biology & Therapy, 17(9), 955–965. https://doi.org/10.1080/15384047.2016.1210736

      Helpful?

  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  3. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  4. 40%ということですが、25ml中10g程度のMGOが含まれるという理解でよろしいでしょうか。

    1 answer

    1. The 40% approximation is mass/mass. In 25 grams of product, there will be 10 grams of methylglyoxal. The density of this preparation is 1.17 g/mL at 25 °C.

      Helpful?

  5. What are the mass and concentration of 25ML methylglyoxal solution?

    1 answer

    1. As per the webpage of M0252: https://www.sigmaaldrich.com/product/sigma/m0252
      The density is 1.17 g/mL at 25 °C (lit.). So the mass of 25 mL = 1.17 x 25 =29.25 g.
      The concentration = Density x w/w% x 1000 / Molecular Weight = 1.17 x 40% x 1000 / 72.06 = 6.49 mol/L.

      Helpful?

  6. Hi I am using this chemical for my research, could you please tell me the molarity of this solution? 

    1 answer

    1. The molarity of the Methylglyoxal solution is approximately 6.49 M. This value may be calculated as follows:
      Molarity = Density x w/w% x 1000 / Mw = 1.17 x 40% x 1000 / 72.06 = 6.49 mol/L

      Helpful?

  7. How to dilute methylglyoxal? What is the stock concentration?

    1 answer

    1. The stock concentration will range from 4.89 M to 8.11 M, depending on the percent methylglyoxal - the specification ranges from 30 % to 50 %. The molecular weight of methylglyoxal is 72.06 g/mol.

      Using the catalog density of 1.17 g/mL at 25 °C, the molarity would calculate to 6.49 molar for a 40 % solution (1,170 g/L × 0.40 = 468 g/L; 468 g/L divided by 72.06 = 6.49 M).

      The actual % concentration is reported on the lot-specific Certificate of Analysis.

      See the link below to access a specific lot or to review a sample Certificate:
      https://www.sigmaaldrich.com/US/en/product/sigma/m0252#product-documentation

      The solution is aqueous and may be further diluted in more water. If diluting with an organic solvent is preferred, ether or alcohols (i.e. ethanol, methanol) are also miscible with water.

      Helpful?

  8. Is the listed density, 1.17 g/ml, for the entire solution i.e. the Methylglyoxal in water or just the Methylglyoxal compound? 

    1 answer

    1. The density is 1.17 g/mL for the prepared solution.

      Helpful?

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