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M5625

Menadion

crystalline

Synonym(e):

2-Methyl-1,4-naphthochinon, Vitamin K3

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Größe/SKUVerfügbarkeitPreis
25 g
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€ 78,80
100 g
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€ 231,00

Über diesen Artikel

Empirische Formel (Hill-System):
C11H8O2
CAS-Nummer:
Molekulargewicht:
172.18
UNSPSC Code:
12352205
NACRES:
NA.79
PubChem Substance ID:
EC Number:
200-372-6
Beilstein/REAXYS Number:
1908453
MDL number:

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biological source

synthetic

Quality Segment

assay

≥98.0% (HPLC)

form

crystalline

technique(s)

HPLC: suitable

color

faint green to green-yellow

mp

105-107 °C (lit.)

solubility

oil: soluble

storage temp.

room temp

SMILES string

CC1=CC(=O)c2ccccc2C1=O

InChI

1S/C11H8O2/c1-7-6-10(12)8-4-2-3-5-9(8)11(7)13/h2-6H,1H3

InChI key

MJVAVZPDRWSRRC-UHFFFAOYSA-N

Gene Information

human ... NQO1(1728)

Application

Menadione has been used for the generation of reactive oxygen species (ROS), followed by flow cytometry analysis. It has also been used in microbiological evaluation, such as to detect fastidious microorganisms.

Biochem/physiol Actions

Menadione is an aromatic polycyclic ketone. It serves as a precursor for vitamin K synthesis. Menadione is converted to menaquinone-4, an active metabolite of vitamin K3. Menadione mediates cell death, by inducing the production of reactive oxygen species through the futile redox cycling.
Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. Menadione is used as a phosphatase inhibitor and an inhibitor of mitochondrial DNA polymerase γ (pol γ). Menadione can be used as an oxidative injury (free radical generator) inducing agent.

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Dieser Artikel
M9429477751381006
Menadion United States Pharmacopeia (USP) Reference Standard

USP

1381006

Menadion

description

crystalline

description

meets USP testing specifications

description

analytical standard

description

United States Pharmacopeia (USP) Reference Standard

technique(s)

HPLC: suitable

technique(s)

-

technique(s)

gas chromatography (GC): suitable, HPLC: suitable

technique(s)

-

biological source

synthetic

biological source

synthetic (organic)

biological source

-

biological source

-

assay

≥98.0% (HPLC)

assay

98.5-101.0% dry basis

assay

-

assay

-

form

crystalline

form

solid

form

-

form

-

solubility

oil: soluble

solubility

-

solubility

-

solubility

-

storage temp.

room temp

storage temp.

-

storage temp.

2-30°C

storage temp.

2-8°C


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Piktogramme

Exclamation markEnvironment

Signalwort

Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Zielorgane

Respiratory system

Lagerklasse

11 - Combustible Solids

Was ist los?

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

PSA (Persönliche Schutzausrüstung)

dust mask type N95 (US), Eyeshields, Faceshields, Gloves



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Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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