M7824

Methotrexat

• Synonym(e): Methotrexat, (+)-Amethopterin, 4-Amino-10-methyl-folsäure, 4-Amino-N¹⁰-methylpteroyl-L-glutaminsäure, Antifolan, MTX, Methylaminopterin
• Empirische Formel (Hill-System): C₂₀H₂₂N₈O₅
• CAS-Nummer: 59-05-2
• Molekulargewicht: 454.44
• EC Number: 200-413-8
• UNSPSC Code: 41116107
• NACRES: NA.21
• Beilstein/REAXYS Number: 70669
• MDL number: MFCD00064370
• eCl@ss: 32120505

Eigenschaften

• biological source: synthetic
• Quality Segment: 400
• form: powder
• suitability: suitable for manufacturing use
• application(s): downstream processes; pharma/biopharma processes; upstream processes
• storage temp.: −20°C
• SMILES string: CN(Cc1cnc2nc(N)nc(N)c2n1)c3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O
• InChI: 1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/t13-/m0/s1
• InChI key: FBOZXECLQNJBKD-ZDUSSCGKSA-N
• Gene Information: human ... DHFR(1719)

Beschreibung

General description

Inhibits thymidylate synthetase, is a nonselective de novo purine synthesis inhibitor and has a significant toxicity profile including hepatotoxicity, pneumonitis and bone marrow suppression. Potent folic acid antagonist. Induces apoptosis in HL-60 human leukemia cells. Also useful as an anti-tumor agent.

Our SAFC^® portfolio of high-quality raw materials for use in biopharmaceutical processing withstands strict quality control procedures plus the documentation and expertise to help our customers meet requirements as defined by the M-Clarity Program.

M-Clarity Program

Our comprehensive portfolio of upstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Trust us to deliver supply chain transparency and reliable sourcing around the globe, streamlining your product qualification with best-in-class regulatory support and service.

Legal Information

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Piktogramme: GHS06,GHS08
• Signalwort: Danger
• Gefahrencodes: H301,H341,H360D,H372
• Sicherheitshinweise: P202 - P260 - P264 - P280 - P301 + P310 - P405
• Hazard Classifications: Acute Tox. 3 Oral - Muta. 2 - Repr. 1B - STOT RE 1
• Zielorgane: Liver,Bone marrow
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable