RAB0166

Phospho-EGFR (pTyr¹⁰⁶⁸) and pan-EGFR ELISA Kit

for detection of human phospho-egfr (pTyr¹⁰⁶⁸) and pan-egfr in cell and tissue lysates

• NACRES: NA.32
• UNSPSC Code: 41116158
• Gene information: human ... EGFR(1965)
• Input: sample type: human cell lysate; sample type: human tissue lysate
• Species reactivity: human
• Storage temp.: −20°C
• Shipped in: wet ice

Eigenschaften

• species reactivity: human
• packaging: kit of 96 wells (12 strips x 8 wells)
• technique(s): ELISA: suitable, capture ELISA: suitable
• input: sample type: human cell lysate; sample type: human tissue lysate
• detection method: colorimetric
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: human ... EGFR(1965)

Beschreibung

General description

The Phospho-EGFR (pTyr¹⁰⁶⁸) ELISA (Enzyme-Linked Immunosorbent Assay) kit is a very rapid, convenient and sensitive assay kit that can monitor the activation or function of important biological pathways in cell lysates.

Immunogen

EGFR (pTyr¹⁰⁶⁸) synthetic phosphopeptide, Recombinant Human EGFR

Application

For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)

Biochem/physiol Actions

EGFR (epidermal growth factor receptor) functions as a receptor for EGF-family of proteins, which are peptide growth factors. This receptor-ligand system is also involved in the pathogenesis and progression of various types of carcinomas. In cancer, EGFR pathways promotes cellular proliferation, angiogenesis, metastasis and apoptosis. The microRNA miR-218-5p interacts with and controls EGFR, and in non-small cell lung cancer (NSCLC), the levels of EGFR are inversely related to miR-218-5p. miR-218-5p inhibits proliferation and migration of lung cancer cells by binding with EGFR, and thus, has potential in future NSCLC therapies. Phospho-EGFR activates phospho-Akt pathway in invasive bladder cancer (BC) and it can be considered as a promising therapeutic target for cancer.

Other Notes

Phosphorylated and pan protien can both be measured , in one experimnet.

Sicherheitshinweise

• Piktogramme: GHS08
• Signalwort: Danger
• Gefahrencodes: H319,H334,H412,EUH430
• Sicherheitshinweise: P261 - P273 - P305 + P351 + P338 - P391 - P405 - P501
• Hazard Classifications: Aquatic Chronic 3 - ED ENV 1 - Eye Irrit. 2 - Resp. Sens. 1
• Lagerklasse: 12 - Non Combustible Liquids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable