In the powder form, this product is stored at 2-8°C. The material is soluble at 2 mg/mL in DMSO. The stability of this product in solution has not been determined. Other sources indicate that aqueous solutions should be prepared fresh daily. This information has not been validated.
Fortfahren mit
SML2283
Lenalidomide
≥98% (HPLC), powder, cereblon binder
Synonym(e):
Lenalidomide, 1-Oxo-4-amino-2-(2,6-dioxopiperidin-3-yl)isoindole, 3-(4-Amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione, 3-(4-Amino-1-oxoisoindolin-2-yl)piperidin-2,6-dione, 3-(4-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione, CC 5013, CC-5013
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| Größe/SKU | Verfügbarkeit | Preis |
|---|---|---|
100 mg | Warenkorb auf Verfügbarkeit prüfen | € 52,30 |
250 mg | Warenkorb auf Verfügbarkeit prüfen | € 118,00 |
Über diesen Artikel
Empirische Formel (Hill-System):
C13H13N3O3
CAS-Nummer:
Molekulargewicht:
259.26
NACRES:
NA.77
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Technischer Dienst
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Unterstützung erhaltenProduktname
Lenalidomide, ≥98% (HPLC)
ligand
lenalidomide
assay
≥98% (HPLC)
form
powder
reaction suitability
reagent type: ligand
technique(s)
targeted protein degradation: suitable
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
O=C1N(C2CCC(NC2=O)=O)CC3=C1C=CC=C3N
InChI
1S/C13H13N3O3/c14-9-3-1-2-7-8(9)6-16(13(7)19)10-4-5-11(17)15-12(10)18/h1-3,10H,4-6,14H2,(H,15,17,18)
InChI key
GOTYRUGSSMKFNF-UHFFFAOYSA-N
Biochem/physiol Actions
Lenalidomide, a derivative of thalidomide, is an immunomodulatory agent that is approved drug for treatment of multiple myeloma. Apparently Lenalidomide is a ligand of ubiquitin E3 ligase cereblon that induces the enzyme to degrade the Ikaros transcription factors IKAROS family zinc finger 1 (IKZF1) and IKZF3. Lenalidomide possess pleiotropic antitumor effects. It is used in the treatment of 5q-deletion associated myelodysplastic syndrome (del(5q)-MDS).
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Dieser Artikel | |||
|---|---|---|---|
| description ≥98% (HPLC) | description ≥95% | description Pharmaceutical Analytical Impurity (PAI) | description Pharmaceutical Analytical Impurity (PAI) |
| form powder | form powder | form - | form - |
| assay ≥98% (HPLC) | assay ≥95% | assay - | assay - |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. -10 to -25°C | storage temp. -10 to -25°C |
| solubility DMSO: 2 mg/mL, clear | solubility - | solubility - | solubility - |
| color white to beige | color - | color - | color - |
| ligand lenalidomide | ligand lenalidomide | ligand - | ligand - |
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Signalwort
Danger
Gefahrencodes
Sicherheitshinweise
Hazard Classifications
Repr. 1B - STOT RE 2
Zielorgane
Blood
Lagerklasse
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Was ist los?
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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