This compound is not listed as being light sensitive. However, the material is air sensitive and packaged under argon. The product is soluble in water and DMSO at 40 mg/mL. The stability of this compound in solution has not been investigated. External sources indicate that aqueous solution may degrade rapidly. Stock solutions in DMSO may be stable for up to 6 months at -20°C and up to 1 years at -80°C when stored in working aliquots. Avoid repeated freeze/thaw cycles.
Fortfahren mit
SML2304
Clozapine N-oxide hydrochloride
≥98% (HPLC), powder, muscarinic DREADD activator
Synonym(e):
Clozapine N-oxide hydrochloride, 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e](1,4)diazepine N-oxide, hydrochloride salt
Anmelden zur Ansicht der Organisations- und Vertragspreise.
Größe auswählen
Ansicht ändern
| Größe/SKU | Verfügbarkeit | Preis |
|---|---|---|
5 mg | Warenkorb auf Verfügbarkeit prüfen | € 250,00 |
Über diesen Artikel
Empirische Formel (Hill-System):
C18H19ClN4O · xHCl
CAS-Nummer:
Molekulargewicht:
342.82 (free base basis)
UNSPSC Code:
12352119
NACRES:
NA.77
eCl@ss:
32160701
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
Technischer Dienst
Benötigen Sie Hilfe? Unser Team von erfahrenen Wissenschaftlern ist für Sie da.
Unterstützung erhaltenProduktname
Clozapine N-oxide hydrochloride, ≥98% (HPLC), Water soluble Clozapine N-oxide
biological source
synthetic
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
solubility
DMSO: 40 mg/mL, water: 40 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
ClC1=CC2=C(NC(C=CC=C3)=C3C(N4CC[N+]([O-])(C)CC4)=N2)C=C1.[xHCl]
InChI
1S/C18H19ClN4O/c1-23(24)10-8-22(9-11-23)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
InChI key
OGUCZBIQSYYWEF-UHFFFAOYSA-N
General description
Clozapine N-oxide hydrochloride is a water soluble form of Clozapine N-oxide (CNO) (Sigma cat# C0832). CNO is a pharmacologically inert metabolite of the atypical anti-psychotic drug clozapine. CNO is a ligand for the engineered Gq protein coupled receptors (GPCRs) in the chemogenetic Designer Receptors Exclusively Activated by Designer Drug (DREADD). The typical use of DREADD is testing, enhancing neuronal firing and activating Gq signaling in neuronal and non-neuronal cells.
The selective targeting of DREADD systems to cell population can be achieved by using a cell type-specific promoter to drive DREADD expression, and the expression of this promoter can be further controlled using a recombinase-based system. DREADDs possess a low affinity for endogenous ligands and little constitutive activity, but may be activated by synthetic compounds such as CNO.
DREADD systems are activated by low nM concentrations of CNO and mobilize intracellular calcium. CNO appears to be pharmacologically and behaviorally inert in mice and rats when administered at the recommended doses (generally 0.1–3 mg/kg). CNO is commonly administrated via injection but also can be mixed into food chow or drinking water.
The selective targeting of DREADD systems to cell population can be achieved by using a cell type-specific promoter to drive DREADD expression, and the expression of this promoter can be further controlled using a recombinase-based system. DREADDs possess a low affinity for endogenous ligands and little constitutive activity, but may be activated by synthetic compounds such as CNO.
DREADD systems are activated by low nM concentrations of CNO and mobilize intracellular calcium. CNO appears to be pharmacologically and behaviorally inert in mice and rats when administered at the recommended doses (generally 0.1–3 mg/kg). CNO is commonly administrated via injection but also can be mixed into food chow or drinking water.
Other Notes
This is not a pharmaceutical grade product.
1 of 1
Dieser Artikel | |||
|---|---|---|---|
| description ≥98% (HPLC), Water soluble Clozapine N-oxide | description - | description United States Pharmacopeia (USP) Reference Standard | description European Pharmacopoeia (EP) Reference Standard |
| assay ≥98% (HPLC) | assay - | assay - | assay - |
| form powder | form solid | form - | form - |
| storage temp. 2-8°C | storage temp. - | storage temp. - | storage temp. - |
| storage condition desiccated | storage condition - | storage condition - | storage condition - |
| solubility DMSO: 40 mg/mL, water: 40 mg/mL | solubility - | solubility - | solubility - |
| shipped in ambient | shipped in - | shipped in - | shipped in - |
Signalwort
Danger
Gefahrencodes
Sicherheitshinweise
Hazard Classifications
Acute Tox. 3 Oral - STOT SE 3
Zielorgane
Central nervous system
Lagerklasse
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Hier finden Sie alle aktuellen Versionen:
Besitzen Sie dieses Produkt bereits?
In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.
-
Is this light-sensitive? Could you provide information about its stability after dissolution at room temperature?
1 answer-
Helpful?
-
-
Is Clozapine N-Oxide pharmaceutical grade?
1 answer-
This is not a pharmaceutical grade product. Unfortunately, a pharmaceutical grade is not offered.
Helpful?
-