SML4205

I-BET787

≥98% (HPLC), powder, pan-BET bromodomain inhibitor

• Synonym(e): 5-[4-Chloro-1-[(tetrahydro-2H-pyran-4-yl)methyl]-1H-imidazol-2-yl]-1,3-dimethyl-2(1H)-pyridinone, 5-(4-Chloro-1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-imidazole-2-yl)-1,3-dimethylpyridin-2(1H)-one
• Empirische Formel (Hill-System): C₁₆H₂₀ClN₃O₂
• CAS-Nummer: 2201082-98-4
• Molekulargewicht: 321.80
• NACRES: NA.21
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C

Beschreibung

Biochem/physiol Actions

Orally active, potent and selective pan-BET family bromodomain (BrD) inhibitor. I-BET787 is an orally active, potent and selective pan-BET bromodomain (BrD) inhibitor (BRD2/3/4/T pIC50 =6.9/7.1/7.1/6.3/BrD1 5.7/6.2/5.9/5.1/BrD2) that demonstrates efficacy in an inflammation model in mice in vivo (5 & 15 mg/kg b.i.d. p.o. for 14 days)by suppressing KLH-TNP (100 μg/kg via i.p. 1h post first I-BET787 oral dosing)-induced T-cell activation.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• Gefahrencodes: H302,H317
• Sicherheitshinweise: P261 - P264 - P272 - P280 - P301 + P312 - P302 + P352
• Hazard Classifications: Acute Tox. 4 Oral - Skin Sens. 1B
• Lagerklasse: 11 - Combustible Solids
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable